Pharmacy, School of: Recent submissions
Now showing items 101-120 of 417
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IDENTIFYING FUNCTIONALLY SELECTIVE LIGANDS FOR THE SEROTONIN-2A RECEPTOR
(University of Kansas, 2017-05-31)Atypical antipsychotics are used to treat schizophrenia and although atypical antipsychotics helped improve the management of positive symptoms, many patients are still suffering from negative and cognitive symptoms and ... -
Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein
(University of Kansas, 2017-05-31)Alpha-synuclein (αSyn) is one of the key proteins considered to be involved in the pathogenesis of the Parkinson`s disease (PD) and being the main component of Lewy bodies (LBs). Studies on the αSyn gene mutants and ... -
Post-translational Modifications of Pregnant X Receptor
(University of Kansas, 2017-05-31)Pregnane X Receptor (PXR, NR1I2) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Expression levels of PXR are highest in the liver and intestine. The activation of PXR can ... -
Review of community pharmacy services: what is being performed, and where are the opportunities for improvement?
(Dove Medical Press, 2017-03-06)OBJECTIVE: The aim of this review was to assess pharmacist and pharmacy services being provided and identify opportunities to improve patient satisfaction. METHODS: Studies published between January 2006 and July 2016 ... -
Iron regulation and heat shock proteins in ischemic stroke
(University of Kansas, 2016-05-31)Ischemic stroke is one of the leading causes of brain injury and death. Many mechanisms underlying ischemia-induced neuronal death have been investigated. Dysregulation of brain iron homeostasis is one of these mechanisms. ... -
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake
(Nature Publishing Group, 2016-01-08)Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express ... -
KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas
(SAE International, 2015-12-24)Lysine deacetylases (KDACs) are enzymes that reverse the post-translational modification of lysine acetylation. Recently, a series of N-acetylthioureas were synthesized and reported to enhance the activity of KDAC8 with a ... -
Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence
(Society for Neuroscience, 2016-03-16)In many human alcoholics, abstinence is self-imposed because of the negative consequences of excessive alcohol use, and relapse is often triggered by exposure to environmental contexts associated with prior alcohol drinking. ... -
Perturbed Brain Energy Metabolism in Alzheimer’s Disease and Diabetes
(University of Kansas, 2017-05-31)The brain has high energy demands, which are met by the complete oxidation of glucose, the obligatory energy substrate for the brain under physiological conditions. Glucose oxidative metabolism consists of cytosolic processes ... -
Identification of sentrin specific proteases and SUMOylation sites of 5-HT1A receptors
(University of Kansas, 2017-08-31)The serotonin-1A receptor (5-HT1A-R) is an abundant 5-HT receptor located in both pre-synaptic and post-synaptic membranes of neurons. Activation of this receptor has been involved in the mechanism of action of antidepressant, ... -
MECHANISMS OF LIVER REGENERATION AFTER ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE
(University of Kansas, 2016-08-31)Overdose of acetaminophen (APAP) is the major cause of acute liver failure (ALF) in the western world with very limited treatment options. Recent studies suggest that liver regeneration is a critical determinant of final ... -
Estrogen Receptor β Regulates Brain Signaling Involved in Depression
(University of Kansas, 2016-08-31)Depression, a common, costly and recurrent disorder is associated with considerable morbidity and excess mortality. Several epidemiological and clinical studies have reported that women exhibit an increased risk for ... -
Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro
(Wiley, 2016-05-11)Variability in response to methotrexate (MTX) in the treatment of juvenile idiopathic arthritis (JIA) remains unpredictable and poorly understood. Based on previous studies implicating an interaction between nicotinamide ... -
Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality
(Nature Publishing Group, 2016-08-02)Interferon regulatory factor 5 (IRF5) is a member of the IRF family of transcription factors. IRF5 was first identified and characterized as a transcriptional regulator of type I interferon expression after virus infection. ... -
Vancomycin 24-Hour Area under the Curve/Minimum Bactericidal Concentration Ratio as a Novel Predictor of Mortality in Methicillin-Resistant Staphylococcus aureus Bacteremia
(American Society for Microbiology, 2016-05)While previous studies have examined the association between vancomycin (VAN) exposure and MIC with regard to outcomes in methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B), none have explored if a relationship ... -
The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
(BioMed Central, 2016-07-08)Hypertriglyceridemia (triglycerides > 150 mg/dL) affects ~25 % of the United States (US) population and is associated with increased cardiovascular risk. Severe hypertriglyceridemia (≥ 500 mg/dL) is also a risk factor for ... -
The chemistry of the blood in measles
(University of Kansas, 1932) -
Role of Yes-Associated Protein (YAP) in Liver Injury and Regeneration following Acetaminophen Overdose
(University of Kansas, 2016-12-31)Acetaminophen (APAP) overdose is the major cause of Acute Liver Failure (ALF) in the Western world. Treatment options for APAP-induced ALF are limited. Studies have shown that stimulating liver regeneration could be a ... -
Identification and characterization of the transporters involved in the disposition of perfluoroalkyl substances
(University of Kansas, 2016-12-31)Perfluoroalkyl substances (PFASs), including perfluoroalkyl carboxylates (PFCAs) and perfluoroalkyl sulfonates (PFSAs), are persistent amphiphilic chemicals many of which are distributed ubiquitously in the environment and ... -
Human ApoE isoforms differentially modulate glucose and amyloid metabolic pathways in female brain: evidence of the mechanism of neuroprotection by ApoE2 and implications for Alzheimer’s prevention and early intervention
(IOS Press, 2015-06-10)Three major genetic isoforms of apolipoprotein E (ApoE) exist in humans, ApoE2, ApoE3, and ApoE4 leading to differences in susceptibility to Alzheimer’s disease (AD). This study investigated the impact of human ApoE isoforms ...