Pharmacy, School of: Recent submissions
Now showing items 321-340 of 417
-
Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs
(Cambridge University Press, 2008-11)Sleep deprivation (SD) is known to induce perceptual impairments, ranging from perceptual distortion to hallucinatory states. Although this phenomenon has been extensively described in the literature, its neurobiological ... -
Monoamine oxidase A and A/B knockout mice display autistic-like features
(Cambridge University Press, 2013-05)Converging lines of evidence show that a sizable subset of autism-spectrum disorders (ASDs) is characterized by increased blood levels of serotonin (5-hydroxytryptamine, 5-HT), yet the mechanistic link between these two ... -
Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin
(Cambridge University Press, 2013-06)Purinergic ionotropic P2X receptors are a family of cation-permeable channels that bind extracellular adenosine 5′-triphosphate. In particular, convergent lines of evidence have recently highlighted P2X4 receptors as a ... -
NMDARs Mediate the Role of Monoamine Oxidase A in Pathological Aggression
(Society for Neuroscience, 2012-06-20)Converging evidence shows that monoamine oxidase A (MAO A), the key enzyme catalyzing serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine (NE) degradation, is a primary factor in the pathophysiology of antisocial and ... -
Maladaptive defensive behaviours in monoamine oxidase A-deficient mice
(Cambridge University Press, 2011-10)Rich evidence indicates that monoamine oxidase (MAO) A, the major enzyme catalysing the degradation of monoamine neurotransmitters, plays a key role in emotional regulation. Although MAOA deficiency is associated with ... -
Role of Hepatocyte Nuclear Factor 4 alpha in Hepatocyte Proliferation
(University of Kansas, 2014-05-31)Hepatocyte Nuclear Factor 4 alpha (HNF4α) is the master regulator of hepatocyte differentiation. It is involved in the up-regulation of genes involved in many classic hepatic functions including: bile acid metabolism, ... -
XENOBIOTIC REGULATION OF THE ATP BINDING CASSETTE TRANSPORTER ABCB6 AND ITS SIGNIFICANCE TO HEPATIC HEME HOMEOSTASIS
(University of Kansas, 2013-12-31)Heme is indispensable for mammalian life. It is an essential component of numerous heme proteins, with functions including oxygen transport and storage, energy metabolism, drug and steroid metabolism and signal transduction. ... -
Ischemia induces different levels of hypoxia inducible factor-1α protein expression in interneurons and pyramidal neurons
(Biomed Central, 2014-05-05)Introduction Pyramidal (glutamatergic) neurons and interneurons are morphologically and functionally well defined in the central nervous system. Although it is known that glutamatergic neurons undergo immediate cell death ... -
Evaluation and implications of natural product use in preoperative patients: a retrospective review
(BioMed Central, 2009-10-13)Background: Medication Reconciliation and Medication Safety are two themes emphasized in a variety of healthcare organizations. As a result, health care facilities have established methods for obtaining a patient's medication ... -
Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum
(Portland Press Limited, 2011-03-29)We have previously shown that overexpression of the Glud1 (glutamate dehydrogenase 1) gene in neurons of C57BL/6 mice results in increased depolarization-induced glutamate release that eventually leads to selective neuronal ... -
Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity
(Portland Press Limited, 2012-04-27)Stroke is a major neurological disorder characterized by an increase in the Glu (glutamate) concentration resulting in excitotoxicity and eventually cellular damage and death in the brain. HIF-1 (hypoxia-inducible factor-1), ... -
Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy
(American Diabetes Association, 2009-08-12)OBJECTIVE Evaluate if Erb B2 activation and the loss of caveolin-1 (Cav1) contribute to the pathophysiological progression of diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS Cav1 knockout and wild-type ... -
Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability
(Bentham Science, 2010-10-21)Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with advancing age and, especially, in neurodegenerative conditions associated with aging, such as Alzheimer’s disease (AD). Yet, deterioration ... -
Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats
(American Diabetes Association, 2011-09-28)OBJECTIVE Impairments in mitochondrial function have been proposed to play a role in the etiology of diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in axons of sensory neurons in type ... -
Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling
(Public Library of Science, 2007-10-24)Bone mass and turnover are maintained by the coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts, under regulation of many systemic and local factors. Phosphoinositide-dependent ... -
Variation in MSRA Modifies Risk of Neonatal Intestinal Obstruction in Cystic Fibrosis
(Public Library of Science, 2012-03-15)Meconium ileus (MI), a life-threatening intestinal obstruction due to meconium with abnormal protein content, occurs in approximately 15 percent of neonates with cystic fibrosis (CF). Analysis of twins with CF demonstrates ... -
Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons
(Public Library of Science, 2013-01-31)Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced ... -
Prenatal Exposure to Urban Air Nanoparticles in Mice Causes Altered Neuronal Differentiation and Depression-Like Responses
(Public Library of Science, 2013-05-29)Emerging evidence suggests that excessive exposure to traffic-derived air pollution during pregnancy may increase the vulnerability to neurodevelopmental alterations that underlie a broad array of neuropsychiatric disorders. ... -
Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrPSc
(Public Library of Science, 2010-07-01)While elucidating the peculiar epitope of the α-PrP mAb IPC2, we found that PrPSc exhibits the sulfoxidation of residue M213 as a covalent signature. Subsequent computational analysis predicted that the presence of sulfoxide ... -
Small Molecule Hsp90 Modulator and Neuregulin-induced Peripheral Demyelination
(University of Kansas, 2012-08-31)Abstract Modulating molecular chaperones is emerging as an attractive approach to treat neurodegenerative diseases associated with protein aggregation, diabetic peripheral neuropathy (DPN) and possibly, demyelinating ...