Pharmacy, School of: Recent submissions
Now showing items 261-280 of 417
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Effect of Duplicate Isolates of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus on Antibiogram Data
(American Society for Microbiology, 2003-03-05) -
(±)-9-exo-Amino-5,6,7,8-tetrahydro-5,8-methano-9H-benzocyclohepten-8-ol Hydrochloride
(International Union of Crystallography, 1978-01-05) -
(±)-2-exo- and endo-Methylamino-1,2,3,4-tetrahydro-1,4-ethanonapthalene Hydrochloride
(International Union of Crystallography, 1978-07-11) -
Nationwide antibiogram analysis using NCCLS M39-A guidelines
(American Society for Microbiology, 2005-06-05)Lack of standardization in antibiogram (ABGM) preparation (the overall profile of antimicrobial susceptibility results of a microbial species to a battery of antimicrobial agents) has not been addressed until recently. The ... -
Striatal expression of a calmodulin fragment improved motor function, weight loss and neuropathology in the R6/2 mouse model of Huntington's disease
(Society for Neuroscience, 2009-09-09)Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a polyglutamine expansion in the huntingtin protein (htt). Increasing evidence suggests that transglutaminase (TGase) plays a critical ... -
Bone Marrow Transplantation Augments the Effect of Brain- and Spinal Cord-Directed AAV2/5 Gene Therapy by Altering Inflammation in the Murine Model of Globoid-Cell Leukodystrophy
(Society for Neuroscience, 2011-04-11)Globoid-cell leukodystrophy (GLD) is an inherited demyelinating disease caused by the deficiency of the lysosomal enzyme galactosylceramidase (GALC). A previous study in the murine model of GLD (twitcher) demonstrated a ... -
Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells
(LumiText Publishing, 2010-09-09)The therapeutic usefulness of anticancer agents relies on their ability to exert maximal toxicity to cancer cells and minimal toxicity to normal cells. The difference between these two parameters defines the therapeutic ... -
Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
(American Society for Microbiology, 2003-06-01)Cellular immune responses, particularly those associated with CD3+ CD8+ cytotoxic T lymphocytes (CTL), play a primary role in controlling viral infection, including persistent infection with human immunodeficiency virus ... -
Anti-proliferative withanolides from the Solanaceae: a structure-activity study
(De Gruyter, 2012-04-01)As part of our search for bioactive compounds from plant biodiversity, 29 withanolides were recently isolated from three members of the Solanaceae: Physalis longifolia, Vassobia breviflora, and Withania somnifera. Six ... -
Withaferin A Induces Proteasome-Dependent Degradation of Breast Cancer Susceptibility Gene 1 and Heat Shock Factor 1 Proteins in Breast Cancer Cells
(Hindawi Publishing Corporation, 2012-06-01)The purpose of this study was to examine the regulation of prosurvival factors heat shock factor 1 (HSF1) and breast cancer susceptibility gene 1 (BRCA1) by a natural withanolide withaferin A (WA) in triple negative breast ... -
The Nuclear Receptor PXR Functions as a Hepatic Lithocholic Acid Sensor
(National Academy of Sciences, 2001-03-13)The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. In ... -
PICK1: a Perinuclear Binding Protein and Substrate for Protein Kinase C Isolated by the Yeast Two-hybrid System
(Rockefeller University Press, 1995-02-01)Protein kinase C (PKC) plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors. Upon activation ... -
Evaluating the Knowledge and Attitudes of Pharmacists and Physicians about Emergency Contraception
(Dove Medical Press, 2010-08-01)No abstract available. -
Evidence that GZ proteins couple to hypothalamic 5-HT1A receptors in vivo
(Society for Neuroscience, 2000-05-01)Using in situ hybridization and immunoblot analysis, the present studies identified Gz mRNA and Gz-protein in the hypothalamic paraventricular nucleus. The role of Gz-proteins in hypothalamic 5-HT1Areceptor signaling was ... -
Calmodulin regulates transglutaminase 2 cross-linking of Huntingtin
(Society for Neuroscience, 2004-02-25)Striatal and cortical intranuclear inclusions and cytoplasmic aggregates of mutant huntingtin are prominent neuropathological hallmarks of Huntington's disease (HD). We demonstrated previously that transglutaminase 2 ... -
Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice
(Society for Neuroscience, 2005-02-02)The microtubule-associated protein tau is highly soluble under physiological conditions. However, in tauopathies, tau protein aggregates into insoluble filaments and neurofibrillary tangles (NFTs). The mechanisms underlying ... -
Characterization of the functional heterologous desensitization of hypothalamic 5-HT1A receptors after 5-HT2A receptor activation
(Society for Neuroscience, 2001-10-15)Desensitization of 5-HT1A receptors could be involved in the long-term therapeutic effect of anxiolytic and antidepressant drugs. Pretreatment of rats with the 5-HT2A/2C agonist DOI induces an attenuation of hypothalamic ... -
Striatal expression of a calmodulin fragment improved motor function, weight loss and neuropathology in the R6/2 mouse model of Huntington's disease
(Society for Neuroscience, 2009-09-16)Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a polyglutamine expansion in the huntingtin protein (htt). Increasing evidence suggests that transglutaminase (TGase) plays a critical ... -
RGS proteins: impact on the treatment of depression and anxiety
(Oxford University Press (OUP), 2012-01-25)No abstract available. -
Physical map location of the peptide methionine sulfoxide reductase gene on the Escherichia coli chromosome
(American Society for Microbiology, 1994-03-01)No abstract available.