Pharmacy, School of: Recent submissions
Now showing items 281-300 of 417
-
Escherichia coli peptide methionine sulfoxide reductase gene:regulation of expression and role in protecting against oxidative damage
(American Society for Microbiology, 1995-02-01)The Escherichia coli peptide methionine sulfoxide reductase gene (msrA) encodes a single-subunit polypeptide of 212 amino acid residues (M. A. Rahman, H. Nelson, H. Weissbach, and N. Brot, J. Biol. Chem. 267:15549-15551, ... -
Using the TAP Component of the Antigen-Processing Machinery as a Molecular Adjuvant
(Public Library of Science, 2005-12-30)We hypothesize that over-expression of transporters associated with antigen processing (TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I antigen-processing pathway, enhances antigen-specific ... -
Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons
(Society for Neuroscience, 1993-11-01)Basic fibroblast growth factor (bFGF) was recently found to modulate the outgrowth-regulating effects of glutamate, and protected neurons from several brain regions against excitotoxi/ischemic damage. We provide evidence ... -
Integrating Multiple Microarray Data for Cancer Pathway Analysis
(Hindawi Publishing Corporation, 2009-06-01)Previous applications of microarray technology for cancer research have mostly focused on identifying genes that are differentially expressed between a particular cancer and normal cells. In a biological system, genes ... -
Selective Neuronal Vulnerability to Oxidative Stress in the Brain
(Frontiers, 2010-03-30)Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other ... -
Bone Marrow Transplantation Alters the Tremor Phenotype in the Murine Model of Globoid-Cell Leukodystrophy
(MDPI, 2012-01-19)Tremor is a prominent phenotype of the twitcher mouse, an authentic genetic model of Globoid-Cell Leukodystrophy (GLD, Krabbe’s disease). In the current study, the tremor was quantified using a force-plate actometer designed ... -
Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles
(BioMed Central, 2003-10-01)We have previously shown that the membrane-associated form of the GABA-synthesizing enzyme, glutamate decarboxylase 65 (GAD65), is activated by synaptic vesicle proton gradient-mediated protein phosphorylation. We now ... -
KU-32, a Novel Drug for Diabetic Neuropathy, is Safe for Human Islets and Improves in vitro Insulin Secretion and Viability
(Hindawi Publishing Corporation, 2012-12-01)KU-32 is a novel, novobiocin-based Hsp90 inhibitor that protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy in a rodent model. However, any drug with potential ... -
Antimicrobial peptides for gram-negative sepsis: a case for the polymyxins
(Frontiers, 2012-08-15)No abstract available. -
Evidence that 5-HT2A Receptors in the Hypothalamic Paraventricular Nucleus Mediate Neuroendocrine Responses to (-)DOI
(Society for Neuroscience, 2002-11-01)The present study determined whether the serotonin2A (5-HT2A) receptors in the hypothalamic paraventricular nucleus mediate the neuroendocrine responses to a peripheral injection of the 5-HT2A/2Creceptor agonist (−)DOI ... -
The impact of omega-3 fatty acid use on the risk of atrial fibrillation in patients with cardiovascular disease
(Scientific Research Publishing, 2011-02-01) -
Secondary prevention following coronary artery bypass surgery: a pilot study for improved patient education
(Scientific Research Publishing, 2012-07-01) -
Reactions of Oxazolinium and Dihydrooxazinium Salts Prepared by an Azide Insertion Sequence: pH Control of Product Distribution
(Thieme Publishing, 1998-11-01) -
Animal models of virus-induced neurobehavioral sequelae: recent advances, methodological issues, and future prospects
(Hindawi Publishing Corporation, 2010-06-01)Converging lines of clinical and epidemiological evidence suggest that viral infections in early developmental stages may be a causal factor in neuropsychiatric disorders such as schizophrenia, bipolar disorder, and ... -
1-Deoxy-D-xylulose 5-phosphate Synthase, the Gene Product of Open Reading Frame (ORF) 2816 and ORF 2895 in Rhodobacter Capsulatus
(American Society for Microbiology, 2001-01-01)In eubacteria, green algae, and plant chloroplasts, isopentenyl diphosphate, a key intermediate in the biosynthesis of isoprenoids, is synthesized by the methylerythritol phosphate pathway. The five carbons of the basic ... -
Optimal Lipid Modification: the Rationale for Combination Therapy
(Dove Medical Press, 2005-01-25)No abstract available. -
Characterization of Peptide-Oligonucleotide Heteroconjugates by Mass Spectrometry
(Oxford University Press, 1996-09-15)Two peptide-oligothymidylic acids, prepared by joining an 11 residue synthetic peptide containing one internal carboxyl group (Asp side chain) to amino-linker-5′pdT6 and amino-linker-5′pdT10 oligonucleotides, were analyzed ... -
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1
(Wiley, 2008-01)Synaptic plasticity is implemented by the interaction of glutamate receptors with PDZ domain proteins. Glutamate transporters provide the only known mechanism of clearance of glutamate from excitatory synapses, and GLT1 ... -
Persistent nonmalignant pain management using nonsteroidal anti-inflammatory drugs in older patients and use of inappropriate adjuvant medications.
(Dove Medical Press, 2015-01-29)Objective Due to the high risk of life-threatening side effects, nonsteroidal anti-inflammatory drugs (NSAIDs) are not favored for treating persistent nonmalignant pain in the elderly. We report national prescription ...