Pharmacy, School of: Recent submissions
Now showing items 221-240 of 417
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The Role of Parkin and Mitophagy in Acetaminophen and Alcohol-induced Liver Injuries
(University of Kansas, 2015-01-01)Acetaminophen (APAP) is the leading cause of acute liver failure in the United States, and alcoholic liver disease (ALD) is a worldwide health problem that claims two million lives per year. Currently, the only cure for ... -
Development of Novel Fluorescence and NMR Reagents for Monitoring Protein-Protein Interactions Between Survivin and Its Protein Binding Partners
(University of Kansas, 2015-08-31)Inhibition of protein-protein interactions is a promising therapeutic strategy for targeting non-enzymatic proteins. One strategy to inhibit protein-protein interactions is to design inhibitors specifically toward the ... -
AN IN VITRO INVESTIGATION INTO THE MECHANISM OF THE CLINICALLY RELEVANT DRUG-DRUG INTERACTION BETWEEN OMEPRAZOLE OR ESOMEPRAZOLE AND CLOPIDOGREL
(University of Kansas, 2015-05-31)Clopidogrel is a thienopyridine antiplatelet prodrug that was approved by the US FDA in 1997 and quickly supplanted ticlopidine as the primary drug therapy for reducing atherothrombotic events. It is converted to its ... -
The role of bile acids during cholestasis in mice and man
(University of Kansas, 2015-05-31)Cholestasis is a reduction in bile flow that occurs during numerous pathologies. Cholestasis leads to significant liver toxicity, biliary hyperplasia, and liver cirrhosis. The molecular mechanisms behind the early liver ... -
SYSTEM-DEPENDENT METABOLISM OF DRUGS BY CYTOCHROME P450: THE MECHANISTIC BASIS FOR WHY HUMAN LIVER MICROSOMES ARE SUPERIOR TO HUMAN HEPATOCYTES AT METABOLIZING MIDAZOLAM BUT INFERIOR AT METABOLIZING DESLORATADINE
(University of Kansas, 2015-05-31)In the pharmaceutical industry, pooled human liver microsomes (HLM) and pooled cryopreserved human hepatocytes (CHH) are the most commonly used test systems to measure the in vitro metabolic intrinsic clearance (CLint) of ... -
Arsenic Toxicity and Altered Mitochondrial Bioenergetics in Response to Oxidative Stress
(University of Kansas, 2015-05-31)Environmental exposure to arsenic is a worldwide health concern which is linked to a number of diseases. Areas with arsenic levels above the current safe concentration have higher levels of skin, lung, liver, and bladder ... -
Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase
(American Society for Microbiology, 2013-05-28)Parasites in the genus Plasmodium cause disease throughout the tropic and subtropical regions of the world. P. falciparum, one of the deadliest species of the parasite, relies on glycolysis for the generation of ATP while ... -
Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents
(American Society for Microbiology, 2010-05)2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a ... -
Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis
(American Society for Microbiology, 2014-05-05)Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective ... -
In Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness
(American Society for Microbiology, 2014-05-27)African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a dipyridylbenzene analogue ... -
Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity
(Oxford University Press, 2014-10-01)Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for ... -
ROLE OF BILE ACIDS AND FARNESOID X RECEPTOR IN HEPATIC AUTOPHAGY AND ITS IMPLICATIONS IN ETHANOL-INDUCED HEPATOTOXICITY
(University of Kansas, 2014-12-31)Retention of bile acids (BAs) in the liver during cholestasis plays an important role in the development of cholestatic liver injury. Several studies have reported that high concentrations of certain BAs induce cell death ... -
Early growth response (Egr)-1: A novel anti-fibrotic mediator in liver
(University of Kansas, 2014-12-31)Chronic alcohol consumption can lead to an aberrant wound healing response of the liver, or hepatic fibrosis. Egr-1 is an essential regulator of many genes involved in the orchestration of tissue injury and repair, yet the ... -
Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death
(BioMed Central, 2014-07-21)Background: 17β-hydroxysteroid dehydrogenase type 10 (HSD10) has been shown to play a protective role in cells undergoing stress. Upregulation of HSD10 under nutrient-limiting conditions leads to recovery of a homeostatic ... -
Severe Hyperosmolar Metabolic Acidosis Due to a Large Dose of Intravenous Lorazepam
(Massachusetts Medical Society, 2002-04-18)No abstract is available for this item. -
Interprofessional Teamwork Skills as Predictors of Clinical Outcomes in a Simulated Healthcare Setting
(Association of Schools of Allied Health Professions, 2013-01)Teaching interprofessional teamwork skills is a goal of interprofessional education. The purpose of this study was to examine the relationship between IP teamwork skills, attitudes and clinical outcomes in a simulated clinical ... -
Community pharmacy-based medication therapy management services: financial impact for patients
(Centro de Investigaciones y Publicaciones Farmaceuticas, 2012-07)Objective: To determine the direct financial impact for patients resulting from Medication Therapy Management (MTM) interventions made by community pharmacists. Secondary objectives include evaluating the patient and ... -
6-Nitrobenzonorbornen-2-one
(International Union of Crystallography, 1982-11)There is no abstract for this article. -
Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability
(Society for Neuroscience, 2009-11-04)The effects of lifelong, moderate excess release of glutamate (Glu) in the CNS have not been previously characterized. We created a transgenic (Tg) mouse model of lifelong excess synaptic Glu release in the CNS by introducing ... -
Structures of two isomeric phenylethanolamine analogs containing the benzobicyclo[3.2.1]octane skeleton
(International Union of Crystallography, 1987)e/ido-8-Amino-6,7,8,9-tetrahydro-5,8- methano-5//-benzocyclohepten-9-ol hydrochloride, C1 2H1 6N0+.C1- Mr = 225-72, tetragonal, IAja, a = b = 24-641(3), c= 7-709 (1) A, F = 4681 (1) A3, Z = 16, D x = 1-281 Mgm~3 , ...