Pharmacy, School of: Recent submissions
Now showing items 201-220 of 417
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UBIQUITINATION AND SUMOYLATION OF PREGNANE X RECEPTOR
(University of Kansas, 2015-05-31)Abstract Pregnane X receptor (PXR, NR1I2) is a ligand-activated nuclear receptor (NR) superfamily member expressed at high levels in the liver and intestine of mammals. PXR can be activated by a broad range of structurally ... -
Intervention with the Hsp90 Modulator KU-32 Improves Chronic Experimental Diabetic Neuropathy
(University of Kansas, 2015-05-31)Inducing the heat shock response (HSR) through Hsp90 inhibition augments heat shock protein (Hsp) support and may improve several aspects of neurodegenerative phenotypes. Several Hsps serve as molecular chaperones that ... -
HSD10 Regulates Cancer Cell Growth and Resistance to Cell Death
(University of Kansas, 2016-05-31)Dysfunction or deregulation of certain cellular processes is commonly used to distinguish known illnesses into separate and unique disease states. Although each cancer type is individually distinct, most cancers initially ... -
THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
(University of Kansas, 2016-05-31)Serotonin 1A receptors (5-HT1A Rs) are implicated in the control of mood, cognition and memory. Dysfunction of 5-HT1A R signaling results in various neuropsychiatric disorders such as depression, anxiety and schizophrenia. ... -
The Dual Role of Hypoxia-Inducible Factor-1 in Ischemic Stroke: Neuroprotection and Blood-Brain Barrier Disruption
(University of Kansas, 2014-08-31)Stroke is a major cause of death and the leading cause of long-term disability in industrialized countries. Ischemic stroke-induced brain injury results from the interaction of complex pathophysiological processes, including ... -
Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
(University of Kansas, 2014-05-31)Aberrant neuron-glia interactions can contribute to a variety of neurodegenerative diseases. We have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth factor receptor ... -
Pregnane X Receptor SUMOylation and De-SUMOylation
(University of Kansas, 2014-05-31)The pregnane x receptor (PXR, NR1I2) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. PXR is activated by numerous lipophilic compounds, a variety of drugs and drug metabolites ... -
The roles of Hypoxia Inducible Factor-1, Glutamate and their interaction in Ischemic Tolerance
(University of Kansas, 2014-05-31)Stroke is a debilitating disorder with no effective treatments. The clinical importance of promoting cerebral ischemic tolerance is apparent; however, our knowledge of the signaling mechanisms involved in the phenomenon ... -
Estradiol-induced desensitization of 5-HT1A receptor signaling
(University of Kansas, 2013-12-31)Depression is a common psychiatric illness, affecting over 120 million people worldwide. Women are affected disproportionately compared to men, and a large body of clinical evidence suggests a role for changes in estrogen ... -
Impact of a community-based diabetes self-management program on key metabolic parameters
(Centro de Investigaciones y Publicaciones Farmaceuticas, 2014-12)OBJECTIVE: Characterize the impact of a pharmacist-led diabetes self-management program on three key metabolic parameters: glycosylated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-C), and mean arterial ... -
Thymoglobulin Induction Dosing Strategies in a Low-Risk Kidney Transplant Population: Three or Four Days?
(Hindawi Publishing Corporation, 2010) -
Medication adherence and glycemic control in patients with psychotic disorders in the Veterans Affairs healthcare system
(Global Research Institute of Pharmacy Practice, 2011-06-17) -
Level, pattern, and determinants of polypharmacy and inappropriate use of medications by village doctors in a rural area of Bangladesh
(Dove Medical Press, 2014-12-03)Objective: Village doctors, informal health care providers practicing modern medicine, are dominant health care providers in rural Bangladesh. Given their role, it is important to examine their prescription pattern and ... -
Agaricus-Montana
(University of Kansas, 1927) -
Health Literacy and Medication Adherence Among Patients Treated in a Free Health Clinic: A Pilot Study
(SAGE Publishing, 2015-06-04)Background: A patient’s health literacy is not routinely assessed during visits with a health care provider. Since low health literacy is a risk factor for poor health outcomes, assessing health literacy should be considered ... -
Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress
(Oxford University Press, 2015-04-24)Background: Acute stress triggers transient alterations in the synaptic release and metabolism of brain monoamine neurotransmitters. These rapid changes are essential to activate neuroplastic processes aimed at the ... -
Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers
(Nature Publishing Group, 2015-08-04) -
Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor
(MDPI, 2015-07-13)Bacillus anthracis adenylyl cyclase toxin edema factor (EF) is one component of the anthrax toxin and is essential for establishing anthrax disease. EF activation by the eukaryotic Ca2+-sensor calmodulin (CaM) leads to ... -
Regulation of Xenobiotic and Bile Acid Metabolism by the Anti-aging Intervention Calorie Restriction in Mice
(University of Kansas, 2013-05-31)Calorie restriction (CR), defined as reduced calorie intake without causing malnutrition, is the best-known intervention to increase life span and slow aging-related diseases in various species. However, current knowledge ... -
STUDY OF FXR IN PRIMARY HUMAN HEPATOCYTES AND FXR REGULATED BA HOMEOSTASIS IN PARENTERAL NUTRITION ASSOCIATED LIVER DISEASES
(University of Kansas, 2014-12-31)Farnesoid X receptor (FXR, NR1H4) is a ligand activated transcription factor belonging to the nuclear receptor (NR) superfamily, and is highly expressed in the liver, intestine, and kidney, in both humans and rodents. Bile ...