Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

View/ Open
Issue Date
2010-05Author
Rogers, Steven A.
Huigens, Robert W., III
Cavanagh, John
Melander, Christian
Publisher
American Society for Microbiology
Type
Article
Article Version
Scholarly/refereed, publisher version
Published Version
10.1128/AAC.01418-09Metadata
Show full item recordAbstract
2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also resensitize multidrug-resistant strains of bacteria to the effects of conventional antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii.
Description
This is the published version.
Collections
- Pharmacy Scholarly Works [293]
Citation
Rogers, S. A., R. W. Huigens, J. Cavanagh, and C. Melander. "Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents." Antimicrobial Agents and Chemotherapy 54.5 (2010): 2112-118. http://dx.doi.org/10.1128/AAC.01418-09
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.