Molecular Biosciences Dissertations and Theses: Recent submissions
Now showing items 261-270 of 270
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Primate Motor Cortex: Individual and Ensemble Neuron-Muscle Output Relationships
(University of Kansas, 2008-07-30)The specific aims of this study were to: 1) investigate the encoding of forelimb muscle activity timing and magnitude by corticomotoneuronal (CM) cells, 2) test the stability of primary motor cortex (M1) output to forelimb ... -
ROLE OF THE Na,K-ATPase IN POLYCYSTIC KIDNEY DISEASE
(University of Kansas, 2008-07-31)Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic disease, and is characterized by multiple fluid-filled cysts that impair the organ, ultimately leading to renal failure. Formation and ... -
TARGETING 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE AND THE SHIKIMATE PATHWAY
(University of Kansas, 2008-08-21)Bacteria, plants, fungi, and apicomplexan parasites require the functionality of the shikimate pathway for biosynthesis of essential aromatic compounds. Animals lack the enzymes that constitute the shikimate pathway, making ... -
CHARACTERIZING THE NUCLEAR LOCALIZATION OF ADENOMATOUS POLYPOSIS COLI PROTEIN
(University of Kansas, 2008-08-18)Mutation of tumor suppressor protein Adenomatous Polyposis Coli (APC) has been shown to be an early, if not rate limiting step in the progression of both hereditary and sporadic colorectal cancers. The observation that APC ... -
CHARACTERIZATION OF INVASION PLASMID ANTIGEN B AND C (IpaB AND IpaC) TRANSLOCATOR COMPLEXES AND TRANSLOCATOR/CHAPERONE COMPLEXES OF Shigella flexneri
(University of Kansas, 2008-08-08)Shigellosis, a severe form of bacillary dysentery, is primarily caused by the gram negative pathogen, Shigella flexneri. In order to elicit disease, the pathogen must pass through the digestive tract and induce its uptake ... -
Cloning and characterization of exc-9, a Caenorhabditis elegans CRIP homologue that regulates tubular structure
(University of Kansas, 2007-10-12)Forming and maintaining tubular structure is fundamental to organismal development. The excretory canal cell of C.elegans forms a single-cell epithelial tubule, which provides a simple model for tubular structure study. ... -
The Biochemistry of Siderophore Biosynthesis
(University of Kansas, 2008-01-25)Pathogenic bacteria are becoming increasingly antibiotic resistant. For this reason, the development of novel antibiotics is extremely important. A potential new target for antimicrobial drugs is the production of siderophores. ... -
Studies of the C-terminal Region of the Gamma Subunit of the Chloroplast ATP Synthase
(University of Kansas, 2008-06-18)The C-terminal region of the γ subunit of the ATP synthase forms a "catch" with an anionic loop on one of the three β subunits within the catalytic αβ hexamer of the F1 segment. A series of single and multiple amino acid ... -
Bacillus subtilis Soj (ParA): The involvement of DNA binding and dynamic localization in plasmid partitioning
(University of Kansas, 2008-05-08)The ParA family of ATPases encompasses proteins with a wide variety of functions. The prototype of this family is the ParA ATPase from the P1 prophage plasmid, which, along with ParB and the parS binding site, is required ... -
Telomerase Regulation and Telomere Maintenance during Human T-cell Leukemia/Lymphoma Virus (HTLV-I) Transformation
(University of Kansas, 2008-04-29)Human T-cell leukemia/lymphoma virus (HTLV-I) is the etiological agent of the lymphoproliferative disorder, adult T-cell leukemia/lymphoma (ATLL) and the neurodegenerative disease, tropical spastic paraparesis/HTLV-I-associated ...