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    CHARACTERIZATION OF INVASION PLASMID ANTIGEN B AND C (IpaB AND IpaC) TRANSLOCATOR COMPLEXES AND TRANSLOCATOR/CHAPERONE COMPLEXES OF Shigella flexneri

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    umi-ku-2535_1.pdf (3.056Mb)
    Issue Date
    2008-08-08
    Author
    Terry, Christina Marie
    Publisher
    University of Kansas
    Format
    109 pages
    Type
    Thesis
    Degree Level
    M.A.
    Discipline
    Molecular Biosciences
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Shigellosis, a severe form of bacillary dysentery, is primarily caused by the gram negative pathogen, Shigella flexneri. In order to elicit disease, the pathogen must pass through the digestive tract and induce its uptake by colonic epithelial cells. To facilitate this process, S. flexneri uses a type III secretion system (TTSS) to form a pore in host cell membranes and deliver translocator and effector proteins to the targeted host cells. Translocon pore formation is the responsibility of the invasion plasmid antigens IpaB and IpaC. Prior to their secretion, IpaB and IpaC are stored in the bacterial cytoplasm where they individually associate with the molecular chaperone IpgC. In this study, a variety of biophysical and molecular techniques were utilized to investigate the structural and functional characteristics of these proteins and the interactions of the translocator/chaperone and the translocator/translocator complexes.
    URI
    http://hdl.handle.net/1808/4155
    Collections
    • Molecular Biosciences Dissertations and Theses [270]
    • Theses [3827]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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