Molecular Biosciences Dissertations and Theses: Recent submissions
Now showing items 141-160 of 270
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MOLECULAR MECHANISMS OF THE DNA DAMAGE RESPONSE INDUCED DURING PARVOVIRUS INFECTION
(University of Kansas, 2012-12-31)DNA damage response (DDR) is a critical safeguarding system to protect genomic stability and integrality through a cascade of phosphorylation events of three PI-3-kinase-like kinases: ATM (ataxia telangiectasia mutated), ... -
OUTPUT FROM MOTOR CORTEX TO CONTRALATERAL AND IPSILATERAL HINDLIMB MUSCLES IN THE PRIMATE
(University of Kansas, 2012-12-31)Although corticospinal control of the forelimb has been heavily studied for several decades, relatively little is known about corticospinal control of the hindlimb despite its importance. The overall goal of this project ... -
THE ROLE OF DMRT1 IN POSTNATAL TESTIS DIFFERENTIATION
(University of Kansas, 2012-01-01)DMRT1 (doublesex and maleabnormal-3 related transcription factor-1) is a transcription regulator that is expressed in Sertoli cells and germ cells of the testis, where it directs mammalian postnatal testis differentiation. ... -
The Development and Validation of a High-throughput Screening Method for Chlamydia trachomatis
(University of Kansas, 2014-05-31)High-throughput screening is a scientific method that can be used to identify small compounds with activity against a number of bacteria and other organisms, as well as diseases, such as cancer, in a cost efficient manner ... -
Calcium signaling components and their effect on synaptic morphology during neuronal development
(University of Kansas, 2014-05-31)Along with regulating synaptic transmission, voltage-gated calcium channel (VGCC) function is responsible for a myriad of cellular outputs, ranging from gene expression to shaping synaptic morphology. Despite the morphological ... -
Interplay Between Viral and Cellular Factors Determines the Fate of Herpes Simplex Virus type I Infection
(University of Kansas, 2014-05-31)The herpes simplex virus type I (HSV-1) is a major human pathogen that infects the majority of the world's population. The life cycle of HSV-1 is controlled by interactions with its hosts. Understanding virus-host interactions ... -
Spatial regulation of cell division by the nucleoid occlusion protein SlmA in Escherichia coli
(University of Kansas, 2014-05-31)Spatial regulation of cell division in bacteria occurs at the stage of Z ring formation, a cytoskeletal element that bacterial cells employ for assembly of the cell division machinery. In the model organism Escherichia ... -
A Method of Differentiating Fibers in Textile Fabrics
(The University of Kansas, 1910) -
Studies of the Micro-Bacillus of Acne and Clinical Studies of Cases Treated by Vaccines
(The University of Kansas, 1911) -
Computational Studies of Protein Structure, Dynamics, and Function in Native-like Environments
(University of Kansas, 2013-05-31)Proteins are among the four unique organic constituents of cells. They are responsible for a variety of important cell functions ranging from providing structural support to catalyzing biological reactions. They vary in ... -
Structural Studies of Chaperones and Chaperone-Tip interactions from the type III secretion systems of Yersinia and Pseudomonas
(University of Kansas, 2013-05-31)Many Gram-negative bacteria assemble a complex nanomachine, the type III secretion system (T3SS) to inject virulence proteins directly into eukaryotic cells to initiate infection. The T3SS is composed of structural and ... -
Computational Studies of Glycan Conformations in Glycoproteins
(University of Kansas, 2013-05-31)N-glycans refer to oligosaccharide chains covalently attached to the side chain of asparagine (Asn) residues, and the majority of proteins synthesized in the endoplasmic reticulum (ER) are N-glycosylated. N-glycans can ... -
STRUCTURAL AND FUNCTIONAL ANALYSIS ON HUMAN INO80 CHROMATIN REMODELING COMPLEXES
(University of Kansas, 2013-12-31)The Conaway lab previously identified and purified a human ATP-dependent chromatin remodeling complex with similarity to the Saccharomyces cerevisiae INO80 complex (65) and demonstrated that it is composed of (i) a Snf2 ... -
CHARACTERIZATION OF THE COHESIN ACETYLTRANSFERASE ECO1 AND ITS ROLE IN NUCLEAR FUNCTIONS
(University of Kansas, 2013-12-31)Sister-chromatid cohesion plays a vital role in precise chromosome segregation and genome stability. This process is carried out by the cohesin complex and its associated proteins. In addition, a growing body of evidence ... -
Mechanisms of cellular symmetry breaking in S. cerevisiae
(University of Kansas, 2013-12-31)Cell polarization is vital to diverse biological processes, from maintenance of stem cell identity to chemotaxis of neutrophils. The small GTPase Cdc42 has long been known to be a primary regulator of polarity, but the ... -
The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells
(Springer, 2014-04-30)Background Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the ... -
1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain
(Structural Biology Communications, 2014-04-01)The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific ... -
Altered Mitochondrial Retrograde Signaling in Response to mtDNA Depletion or a Ketogenic Diet
(University of Kansas, 2012-12-31)Neurodegenerative diseases affect a staggering proportion of the population. Many neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease exhibit significant metabolic ... -
Oogenesis in Unisexual Whiptail Lizards (genus Aspidoscelis)
(University of Kansas, 2012-12-31)Parthenogenesis is a reproductive mode that does not require males. Though theoretically advantageous, its rarity among metazoans suggests otherwise. Paradoxically, some unisexual species within the genus Aspidoscelis ... -
Genetic Analysis of Allosteric Signaling in RhaR from Escherichia coli and Characterization of the VirF Protein from Shigella flexneri
(University of Kansas, 2013-12-31)The RhaR and VirF proteins are both members of the large AraC family of bacterial transcription regulators. RhaR activates expression of the Escherichia coli rhaSR operon in response to the effector L-rhamnose while VirF ...