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Inhibition of ICAM-1/LFA-1-mediated Heterotypic T-cell Adhesion to Epithelial Cells: Design of ICAM-1 Cyclic Peptides
| dc.contributor.author | Anderson, Meagan E. | |
| dc.contributor.author | Yakovleva, Tatyana | |
| dc.contributor.author | Yongbo, Hu | |
| dc.contributor.author | Siahaan, Teruna J. | |
| dc.date.accessioned | 2011-06-23T19:22:30Z | |
| dc.date.available | 2011-06-23T19:22:30Z | |
| dc.date.issued | 2004-03 | |
| dc.identifier.citation | M.E. Anderson, T. Yakovleva, Y. Hu, and T. J. Siahaan, "Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: Design of ICAM-1 cyclic peptides," Bioorg. Med. Chem. Lett. 14, 1399–1402 (2004). [PMID: 15006370] http://dx.doi.org/10.1016/j.bmcl.2003.09.100 | |
| dc.identifier.uri | http://hdl.handle.net/1808/7704 | |
| dc.description | DOI: 10.1016/j.bmcl.2003.09.100 | |
| dc.description.abstract | In this work, we have designed cyclic peptides (cIBL, cIBR, cIBC, CH4 and CH7) derived from the parent IB peptide (ICAM-11–21) that are inhibitors of ICAM-1/LFA-1-mediated T-cell adhesion to Caco-2 cell monolayers. Cyclic peptide cIBR has the best activity of any of the peptides evaluated. The active ICAM-1 peptides have a common Pro-Arg-Gly sequence that may be important for binding to LFA-1. | |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | |
| dc.title | Inhibition of ICAM-1/LFA-1-mediated Heterotypic T-cell Adhesion to Epithelial Cells: Design of ICAM-1 Cyclic Peptides | |
| dc.type | Article | |
| kusw.kuauthor | Siahaan, Teruna J. | |
| kusw.kudepartment | Pharmaceutical Chemistry | |
| kusw.oastatus | fullparticipation | |
| dc.identifier.doi | 10.1016/j.bmcl.2003.09.100 | |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | |
| dc.rights.accessrights | openAccess |
