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dc.contributor.authorAnderson, Meagan E.
dc.contributor.authorYakovleva, Tatyana
dc.contributor.authorYongbo, Hu
dc.contributor.authorSiahaan, Teruna J.
dc.date.accessioned2011-06-23T19:22:30Z
dc.date.available2011-06-23T19:22:30Z
dc.date.issued2004-03
dc.identifier.citationM.E. Anderson, T. Yakovleva, Y. Hu, and T. J. Siahaan, "Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: Design of ICAM-1 cyclic peptides," Bioorg. Med. Chem. Lett. 14, 1399–1402 (2004). [PMID: 15006370] http://dx.doi.org/10.1016/j.bmcl.2003.09.100
dc.identifier.urihttp://hdl.handle.net/1808/7704
dc.descriptionDOI: 10.1016/j.bmcl.2003.09.100
dc.description.abstractIn this work, we have designed cyclic peptides (cIBL, cIBR, cIBC, CH4 and CH7) derived from the parent IB peptide (ICAM-11–21) that are inhibitors of ICAM-1/LFA-1-mediated T-cell adhesion to Caco-2 cell monolayers. Cyclic peptide cIBR has the best activity of any of the peptides evaluated. The active ICAM-1 peptides have a common Pro-Arg-Gly sequence that may be important for binding to LFA-1.
dc.language.isoen_US
dc.publisherElsevier
dc.titleInhibition of ICAM-1/LFA-1-mediated Heterotypic T-cell Adhesion to Epithelial Cells: Design of ICAM-1 Cyclic Peptides
dc.typeArticle
kusw.kuauthorSiahaan, Teruna J.
kusw.kudepartmentPharmaceutical Chemistry
kusw.oastatusfullparticipation
dc.identifier.doi10.1016/j.bmcl.2003.09.100
kusw.oaversionScholarly/refereed, author accepted manuscript
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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