In this work, we have designed cyclic peptides (cIBL, cIBR, cIBC, CH4 and CH7) derived from the parent IB peptide (ICAM-11–21) that are inhibitors of ICAM-1/LFA-1-mediated T-cell adhesion to Caco-2 cell monolayers. Cyclic peptide cIBR has the best activity of any of the peptides evaluated. The active ICAM-1 peptides have a common Pro-Arg-Gly sequence that may be important for binding to LFA-1.
M.E. Anderson, T. Yakovleva, Y. Hu, and T. J. Siahaan, "Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: Design of ICAM-1 cyclic peptides," Bioorg. Med. Chem. Lett. 14, 1399–1402 (2004). [PMID: 15006370] http://dx.doi.org/10.1016/j.bmcl.2003.09.100
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