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AURORA KINASES IN SOLELY ESTROGEN-INDUCED ONCOGENESIS: RELATION TO CENTROSOME AMPLIFICATION AND CHROMOSOMAL INSTABILITY
dc.contributor.advisor | Li, Jonathan J | |
dc.contributor.advisor | Li, Sara A | |
dc.contributor.author | Hontz, Adrianne Elizabeth | |
dc.date.accessioned | 2008-09-29T05:06:34Z | |
dc.date.available | 2008-09-29T05:06:34Z | |
dc.date.issued | 2008-06-02 | |
dc.date.submitted | 2008 | |
dc.identifier.other | http://dissertations2.umi.com/ku:2589 | |
dc.identifier.uri | http://hdl.handle.net/1808/4234 | |
dc.description.abstract | Estrogens play a crucial role in the causation and development of sporadic breast cancer, which accounts for ~ 90 - 95% of all breast cancer cases. To understand the molecular and cellular events involved in solely estrogen-induced oncogenesis, we studied the role of mitotic kinases, Aurora A and B, and the MDM2-p53wt pathway in estrogen-elicited oncogenesis, using two animal tumor models, the estrogen-induced tumors of the kidney in male Syrian hamsters, and the mammary gland in female ACI rats. Evidence is presented indicating that both Aurora kinase and MDM2 over-expression are under estrogen control in both tumor models studied. Our data further show that estrogens, interacting with the estrogen receptor α, elicit persistent Aurora A kinase over expression that may affect abnormal centrosome duplication, and together with the loss of p53wt activity by the over expression of MDM2 lead to estrogen-induced oncogenesis. | |
dc.format.extent | 180 pages | |
dc.language.iso | EN | |
dc.publisher | University of Kansas | |
dc.rights | This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author. | |
dc.subject | Health sciences | |
dc.subject | Oncology | |
dc.subject | Pharmacology | |
dc.subject | Molecular biology | |
dc.subject | Breast cancer | |
dc.subject | Estrogen | |
dc.subject | Aurora kinases | |
dc.subject | Centrosome amplification | |
dc.subject | Chromosomal instability | |
dc.subject | Aneuploidy | |
dc.title | AURORA KINASES IN SOLELY ESTROGEN-INDUCED ONCOGENESIS: RELATION TO CENTROSOME AMPLIFICATION AND CHROMOSOMAL INSTABILITY | |
dc.type | Dissertation | |
dc.contributor.cmtemember | Enna, S. J. | |
dc.contributor.cmtemember | Pazdernik, Thomas L. | |
dc.contributor.cmtemember | Robertson, John D. | |
dc.contributor.cmtemember | Tawfik, Ossama | |
dc.thesis.degreeDiscipline | Pharmacology, Toxicology & Therapeutics | |
dc.thesis.degreeLevel | PH.D. | |
kusw.oastatus | na | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
kusw.bibid | 6857240 | |
dc.rights.accessrights | openAccess |
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Dissertations [4889]
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Pharmacy Dissertations and Theses [118]