dc.contributor.author | Greenberg, E. Peter | |
dc.contributor.author | Chandler, Josephine R. | |
dc.contributor.author | Seyedsayamdost, Mohammad R. | |
dc.date.accessioned | 2022-01-18T14:49:54Z | |
dc.date.available | 2022-01-18T14:49:54Z | |
dc.date.issued | 2020-02-27 | |
dc.identifier.citation | Greenberg, E. P., Chandler, J. R., & Seyedsayamdost, M. R. (2020). The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. Journal of natural products, 83(3), 738–743. https://doi.org/10.1021/acs.jnatprod.9b01237 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32425 | |
dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see doi.org/10.1021/acs.jnatprod.9b01237. | en_US |
dc.description.abstract | Bactobolin is a hybrid natural product with potent cytotoxic activity. Its production from Burkholderia thailandensis was reported as part of a collaboration between the Greenberg and Clardy laboratories in 2010. The collaboration sparked a series of studies leading to the discovery of new analogues and associated structure–activity relationships, the identification of the bactobolin biosynthetic gene cluster and assembly of its unusual amino acid building block, the molecular target of and resistance to the antibiotic, and finally an X-ray crystal structure of the ribosome–bactobolin complex. Herein, we review the collaborations that led to our current understanding of the chemistry and biology of bactobolin. | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | Copyright © 2020 American Chemical Society and American Society of Pharmacognosy | en_US |
dc.title | The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Chandler, Josephine R. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1021/acs.jnatprod.9b01237 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0001-9474-8041 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0003-2707-4854 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC8118907 | en_US |
dc.rights.accessrights | openAccess | en_US |