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Resistance to natural and synthetic gene drive systems

dc.contributor.authorPrice, Tom A. R.
dc.contributor.authorWindbichler, Nikolai
dc.contributor.authorUnckless, Robert L.
dc.contributor.authorSutter, Andreas
dc.contributor.authorRunge, Jan-Niklas
dc.contributor.authorRoss, Perran A.
dc.contributor.authorPomiankowski, Andrew
dc.contributor.authorNuckolls, Nicole L.
dc.contributor.authorMontchamp-Moreau, Catherine
dc.contributor.authorMideo, Nicole
dc.contributor.authorMartin, Oliver Y.
dc.contributor.authorManser, Andri
dc.contributor.authorLegros, Matthieu
dc.contributor.authorLarracuente, Amanda M.
dc.contributor.authorHolman, Luke
dc.contributor.authorGodwin, John
dc.contributor.authorGemmell, Neil
dc.contributor.authorCourret, Cécile
dc.contributor.authorBuchman, Anna
dc.contributor.authorBarrett, Luke G.
dc.contributor.authorLindholm, Anna K.
dc.date.accessioned2022-01-10T21:39:57Z
dc.date.available2022-01-10T21:39:57Z
dc.date.issued2020-09-24
dc.identifier.citationPrice, T., Windbichler, N., Unckless, R. L., Sutter, A., Runge, J. N., Ross, P. A., Pomiankowski, A., Nuckolls, N. L., Montchamp-Moreau, C., Mideo, N., Martin, O. Y., Manser, A., Legros, M., Larracuente, A. M., Holman, L., Godwin, J., Gemmell, N., Courret, C., Buchman, A., Barrett, L. G., … Lindholm, A. K. (2020). Resistance to natural and synthetic gene drive systems. Journal of evolutionary biology, 33(10), 1345–1360. https://doi.org/10.1111/jeb.13693en_US
dc.identifier.urihttp://hdl.handle.net/1808/32385
dc.description.abstractScientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.en_US
dc.publisherWileyen_US
dc.rights© 2020 The Authors. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCRISPR-Cas9en_US
dc.subjectFitness costsen_US
dc.subjectMeiotic driveen_US
dc.subjectPopulation suppressionen_US
dc.subjectSelfish genetic elementsen_US
dc.subjectSex ratio distorteren_US
dc.subjectTransposable elementsen_US
dc.subjectWolbachiaen_US
dc.titleResistance to natural and synthetic gene drive systemsen_US
dc.typeArticleen_US
kusw.kuauthorUnckless, Robert L.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1111/jeb.13693en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-4394-6301en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-9896-1165en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-8586-7137en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-7764-3456en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-0450-9897en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-7645-7523en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-5171-8755en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-7088-7944en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-5044-9709en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-8719-3620en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-8601-7131en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-4296-7434en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0003-3807-8594en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-5944-5686en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-7268-2173en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-0928-501Xen_US
dc.identifier.orcidhttps://orcid.org/ 0000-0003-0671-3637en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-5849-8014en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-8775-6147en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6530-0731en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-8460-9769en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7796552en_US
dc.rights.accessrightsopenAccessen_US


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© 2020 The Authors. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as: © 2020 The Authors. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.