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dc.contributor.authorColella, Jocelyn P.
dc.contributor.authorTigano, Anna
dc.contributor.authorDudchenko, Olga
dc.contributor.authorOmer, Arina D.
dc.contributor.authorKhan, Ruqayya
dc.contributor.authorBochkov, Ivan D.
dc.contributor.authorAiden, Erez L.
dc.contributor.authorMacManes, Matthew D.
dc.date.accessioned2022-01-04T21:31:25Z
dc.date.available2022-01-04T21:31:25Z
dc.date.issued2021-03-04
dc.identifier.citationJocelyn P Colella, Anna Tigano, Olga Dudchenko, Arina D Omer, Ruqayya Khan, Ivan D Bochkov, Erez L Aiden, Matthew D MacManes, Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice, Journal of Heredity, Volume 112, Issue 3, May 2021, Pages 286–302, https://doi.org/10.1093/jhered/esab009en_US
dc.identifier.urihttp://hdl.handle.net/1808/32330
dc.description.abstractWarming climate and increasing desertification urge the identification of genes involved in heat and dehydration tolerance to better inform and target biodiversity conservation efforts. Comparisons among extant desert-adapted species can highlight parallel or convergent patterns of genome evolution through the identification of shared signatures of selection. We generate a chromosome-level genome assembly for the canyon mouse (Peromyscus crinitus) and test for a signature of parallel evolution by comparing signatures of selective sweeps across population-level genomic resequencing data from another congeneric desert specialist (Peromyscus eremicus) and a widely distributed habitat generalist (Peromyscus maniculatus), that may be locally adapted to arid conditions. We identify few shared candidate loci involved in desert adaptation and do not find support for a shared pattern of parallel evolution. Instead, we hypothesize divergent molecular mechanisms of desert adaptation among deer mice, potentially tied to species-specific historical demography, which may limit or enhance adaptation. We identify a number of candidate loci experiencing selective sweeps in the P. crinitus genome that are implicated in osmoregulation (Trypsin, Prostasin) and metabolic tuning (Kallikrein, eIF2-alpha kinase GCN2, APPL1/2), which may be important for accommodating hot and dry environmental conditions.en_US
dc.publisherOxford University Pressen_US
dc.rights© The American Genetic Association. 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectDehydrationen_US
dc.subjectDeserten_US
dc.subjectParallel evolutionen_US
dc.subjectPeromyscusen_US
dc.subjectThermoregulationen_US
dc.titleLimited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Miceen_US
dc.typeArticleen_US
kusw.kuauthorColella, Jocelyn P.
kusw.kudepartmentBiodiversity Instituteen_US
dc.identifier.doi10.1093/jhered/esab009en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-2368-6960en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC8141686en_US
dc.rights.accessrightsopenAccessen_US


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© The American Genetic Association. 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as: © The American Genetic Association. 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.