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Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice
dc.contributor.author | Colella, Jocelyn P. | |
dc.contributor.author | Tigano, Anna | |
dc.contributor.author | Dudchenko, Olga | |
dc.contributor.author | Omer, Arina D. | |
dc.contributor.author | Khan, Ruqayya | |
dc.contributor.author | Bochkov, Ivan D. | |
dc.contributor.author | Aiden, Erez L. | |
dc.contributor.author | MacManes, Matthew D. | |
dc.date.accessioned | 2022-01-04T21:31:25Z | |
dc.date.available | 2022-01-04T21:31:25Z | |
dc.date.issued | 2021-03-04 | |
dc.identifier.citation | Jocelyn P Colella, Anna Tigano, Olga Dudchenko, Arina D Omer, Ruqayya Khan, Ivan D Bochkov, Erez L Aiden, Matthew D MacManes, Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice, Journal of Heredity, Volume 112, Issue 3, May 2021, Pages 286–302, https://doi.org/10.1093/jhered/esab009 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32330 | |
dc.description.abstract | Warming climate and increasing desertification urge the identification of genes involved in heat and dehydration tolerance to better inform and target biodiversity conservation efforts. Comparisons among extant desert-adapted species can highlight parallel or convergent patterns of genome evolution through the identification of shared signatures of selection. We generate a chromosome-level genome assembly for the canyon mouse (Peromyscus crinitus) and test for a signature of parallel evolution by comparing signatures of selective sweeps across population-level genomic resequencing data from another congeneric desert specialist (Peromyscus eremicus) and a widely distributed habitat generalist (Peromyscus maniculatus), that may be locally adapted to arid conditions. We identify few shared candidate loci involved in desert adaptation and do not find support for a shared pattern of parallel evolution. Instead, we hypothesize divergent molecular mechanisms of desert adaptation among deer mice, potentially tied to species-specific historical demography, which may limit or enhance adaptation. We identify a number of candidate loci experiencing selective sweeps in the P. crinitus genome that are implicated in osmoregulation (Trypsin, Prostasin) and metabolic tuning (Kallikrein, eIF2-alpha kinase GCN2, APPL1/2), which may be important for accommodating hot and dry environmental conditions. | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | © The American Genetic Association. 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Dehydration | en_US |
dc.subject | Desert | en_US |
dc.subject | Parallel evolution | en_US |
dc.subject | Peromyscus | en_US |
dc.subject | Thermoregulation | en_US |
dc.title | Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Colella, Jocelyn P. | |
kusw.kudepartment | Biodiversity Institute | en_US |
dc.identifier.doi | 10.1093/jhered/esab009 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-2368-6960 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC8141686 | en_US |
dc.rights.accessrights | openAccess | en_US |