Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice

View/ Open
Issue Date
2021-03-04Author
Colella, Jocelyn P.
Tigano, Anna
Dudchenko, Olga
Omer, Arina D.
Khan, Ruqayya
Bochkov, Ivan D.
Aiden, Erez L.
MacManes, Matthew D.
Publisher
Oxford University Press
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© The American Genetic Association. 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
Metadata
Show full item recordAbstract
Warming climate and increasing desertification urge the identification of genes involved in heat and dehydration tolerance to better inform and target biodiversity conservation efforts. Comparisons among extant desert-adapted species can highlight parallel or convergent patterns of genome evolution through the identification of shared signatures of selection. We generate a chromosome-level genome assembly for the canyon mouse (Peromyscus crinitus) and test for a signature of parallel evolution by comparing signatures of selective sweeps across population-level genomic resequencing data from another congeneric desert specialist (Peromyscus eremicus) and a widely distributed habitat generalist (Peromyscus maniculatus), that may be locally adapted to arid conditions. We identify few shared candidate loci involved in desert adaptation and do not find support for a shared pattern of parallel evolution. Instead, we hypothesize divergent molecular mechanisms of desert adaptation among deer mice, potentially tied to species-specific historical demography, which may limit or enhance adaptation. We identify a number of candidate loci experiencing selective sweeps in the P. crinitus genome that are implicated in osmoregulation (Trypsin, Prostasin) and metabolic tuning (Kallikrein, eIF2-alpha kinase GCN2, APPL1/2), which may be important for accommodating hot and dry environmental conditions.
Collections
Citation
Jocelyn P Colella, Anna Tigano, Olga Dudchenko, Arina D Omer, Ruqayya Khan, Ivan D Bochkov, Erez L Aiden, Matthew D MacManes, Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice, Journal of Heredity, Volume 112, Issue 3, May 2021, Pages 286–302, https://doi.org/10.1093/jhered/esab009
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.