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dc.contributor.authorMoon, Hee-Jung
dc.contributor.authorFinney, Joel
dc.contributor.authorRonnebaum, Trey
dc.contributor.authorMure, Minae
dc.identifier.citationHee-Jung Moon, Joel Finney, Trey Ronnebaum, Minae Mure. Bioorg Chem. 2014 Dec; 57: 231–241. Published online 2014 Aug 1. doi: 10.1016/j.bioorg.2014.07.003en_US
dc.descriptionThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en_US
dc.description.abstractLysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu2+- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2.en_US
dc.rightsCopyright © 2014 Elsevier Inc. All rights reserved.en_US
dc.subjectLysyl oxidase familyen_US
dc.subjectLysyl oxidase like-2en_US
dc.subjectLysine tyrosylquinone (LTQ)en_US
dc.subjectCell signalingen_US
dc.subjectExtracellular matrixen_US
dc.subjectTumor metastasis/invasionen_US
dc.titleHuman lysyl oxidase-like 2en_US
kusw.kuauthorMoon, Hee-Jung
kusw.kuauthorFinney, Joel
kusw.kuauthorRonnebaum, Trey
kusw.kuauthorMure, Minae
kusw.kudepartmentDepartment of Chemistryen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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Copyright © 2014 Elsevier Inc. All rights reserved.
Except where otherwise noted, this item's license is described as: Copyright © 2014 Elsevier Inc. All rights reserved.