Human lysyl oxidase-like 2
| dc.contributor.author | Moon, Hee-Jung | |
| dc.contributor.author | Finney, Joel | |
| dc.contributor.author | Ronnebaum, Trey | |
| dc.contributor.author | Mure, Minae | |
| dc.date.accessioned | 2021-10-05T20:30:06Z | |
| dc.date.available | 2021-10-05T20:30:06Z | |
| dc.date.issued | 2014-08-01 | |
| dc.identifier.citation | Hee-Jung Moon, Joel Finney, Trey Ronnebaum, Minae Mure. Bioorg Chem. 2014 Dec; 57: 231–241. Published online 2014 Aug 1. doi: 10.1016/j.bioorg.2014.07.003 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/31904 | |
| dc.description | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | en_US |
| dc.description.abstract | Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu2+- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2. | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | Copyright © 2014 Elsevier Inc. All rights reserved. | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.subject | Lysyl oxidase family | en_US |
| dc.subject | Lysyl oxidase like-2 | en_US |
| dc.subject | Lysine tyrosylquinone (LTQ) | en_US |
| dc.subject | Cell signaling | en_US |
| dc.subject | Extracellular matrix | en_US |
| dc.subject | Tumor metastasis/invasion | en_US |
| dc.title | Human lysyl oxidase-like 2 | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Moon, Hee-Jung | |
| kusw.kuauthor | Finney, Joel | |
| kusw.kuauthor | Ronnebaum, Trey | |
| kusw.kuauthor | Mure, Minae | |
| kusw.kudepartment | Department of Chemistry | en_US |
| dc.identifier.doi | 10.1016/j.bioorg.2014.07.003 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC6309629 | en_US |
| dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: Copyright © 2014 Elsevier Inc. All rights reserved.
