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The phage gene wmk is a candidate for male killing by a bacterial endosymbiont
dc.contributor.author | Perlmutter, Jessamyn I. | |
dc.contributor.author | Bordenstein, Sarah R. | |
dc.contributor.author | Unckless, Robert L. | |
dc.contributor.author | LePage, Daniel P. | |
dc.contributor.author | Metcalf, Jason A. | |
dc.contributor.author | Hill, Tom | |
dc.contributor.author | Martinez, Julien | |
dc.contributor.author | Jiggins, Francis M. | |
dc.contributor.author | Bordenstein, Seth R. | |
dc.date.accessioned | 2021-02-23T23:02:40Z | |
dc.date.available | 2021-02-23T23:02:40Z | |
dc.date.issued | 2019-09-10 | |
dc.identifier.citation | Perlmutter JI, Bordenstein SR, Unckless RL, LePage DP, Metcalf JA, Hill T, et al. (2019) The phage gene wmk is a candidate for male killing by a bacterial endosymbiont. PLoS Pathog 15(9): e1007936. https://doi.org/10.1371/journal.ppat.1007936 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/31467 | |
dc.description.abstract | Wolbachia are the most widespread maternally-transmitted bacteria in the animal kingdom. Their global spread in arthropods and varied impacts on animal physiology, evolution, and vector control are in part due to parasitic drive systems that enhance the fitness of infected females, the transmitting sex of Wolbachia. Male killing is one common drive mechanism wherein the sons of infected females are selectively killed. Despite decades of research, the gene(s) underlying Wolbachia-induced male killing remain unknown. Here using comparative genomic, transgenic, and cytological approaches in fruit flies, we identify a candidate gene in the eukaryotic association module of Wolbachia prophage WO, termed WO-mediated killing (wmk), which transgenically causes male-specific lethality during early embryogenesis and cytological defects typical of the pathology of male killing. The discovery of wmk establishes new hypotheses for the potential role of phage genes in sex-specific lethality, including the control of arthropod pests and vectors. | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2019 Perlmutter et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.title | The phage gene wmk is a candidate for male killing by a bacterial endosymbiont | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Unckless, Robert L. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1371/journal.ppat.1007936 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-9789-4674 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-6092-1950 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-8586-7137 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-4661-6391 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-8210-2921 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-7470-8157 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-7346-0954 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © 2019 Perlmutter et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.