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dc.contributor.authorDuxbury, Elizabeth M. L.
dc.contributor.authorDay, Jonathan P.
dc.contributor.authorVespasiani, Davide Maria
dc.contributor.authorThüringer, Yannik
dc.contributor.authorTolosana, Ignacio
dc.contributor.authorSmith, Sophia C. L.
dc.contributor.authorTagliaferri, Lucia
dc.contributor.authorKamacioglu, Altug
dc.contributor.authorLindsley, Imogen
dc.contributor.authorLove, Luca
dc.contributor.authorUnckless, Robert L.
dc.contributor.authorJiggins, Francis M.
dc.contributor.authorLongdon, Ben
dc.identifier.citationeLife 2019;8:e46440en_US
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractIt is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of Drosophila and four host-specific viruses, we always found greater genetic variation in susceptibility to viruses that had coevolved with their host. We went on to examine the genetic architecture of resistance in one host species, finding that there are more major-effect genetic variants in coevolved host-pathogen interactions. We conclude that selection by pathogens has increased genetic variation in host susceptibility, and much of this effect is caused by the occurrence of major-effect resistance polymorphisms within populations.en_US
dc.publishereLife Sciences Publicationsen_US
dc.rights© 2019, Duxbury et al.en_US
dc.titleHost-pathogen coevolution increases genetic variation in susceptibility to infectionen_US
kusw.kuauthorUnckless, Robert L.
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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© 2019, Duxbury et al.
Except where otherwise noted, this item's license is described as: © 2019, Duxbury et al.