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Host-pathogen coevolution increases genetic variation in susceptibility to infection
dc.contributor.author | Duxbury, Elizabeth M. L. | |
dc.contributor.author | Day, Jonathan P. | |
dc.contributor.author | Vespasiani, Davide Maria | |
dc.contributor.author | Thüringer, Yannik | |
dc.contributor.author | Tolosana, Ignacio | |
dc.contributor.author | Smith, Sophia C. L. | |
dc.contributor.author | Tagliaferri, Lucia | |
dc.contributor.author | Kamacioglu, Altug | |
dc.contributor.author | Lindsley, Imogen | |
dc.contributor.author | Love, Luca | |
dc.contributor.author | Unckless, Robert L. | |
dc.contributor.author | Jiggins, Francis M. | |
dc.contributor.author | Longdon, Ben | |
dc.date.accessioned | 2021-01-07T21:22:19Z | |
dc.date.available | 2021-01-07T21:22:19Z | |
dc.date.issued | 2019-04-30 | |
dc.identifier.citation | eLife 2019;8:e46440 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/31061 | |
dc.description | This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.description.abstract | It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of Drosophila and four host-specific viruses, we always found greater genetic variation in susceptibility to viruses that had coevolved with their host. We went on to examine the genetic architecture of resistance in one host species, finding that there are more major-effect genetic variants in coevolved host-pathogen interactions. We conclude that selection by pathogens has increased genetic variation in host susceptibility, and much of this effect is caused by the occurrence of major-effect resistance polymorphisms within populations. | en_US |
dc.publisher | eLife Sciences Publications | en_US |
dc.rights | © 2019, Duxbury et al. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.title | Host-pathogen coevolution increases genetic variation in susceptibility to infection | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Unckless, Robert L. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.7554/eLife.46440 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-5733-3645 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-3766-8296 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-8586-7137 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-7470-8157 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-6936-1697 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |