Show simple item record

dc.contributor.authorAl-Hashimi, Hikmat
dc.contributor.authorChiarelli, Travis
dc.contributor.authorLundquist, Erik A.
dc.contributor.authorBuechner, Matthew
dc.identifier.citationAl-Hashimi, H., Chiarelli, T., Lundquist, E. A., & Buechner, M. (2019). Novel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegans. G3 (Bethesda, Md.), 9(5), 1339–1353.
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractRegulation of luminal diameter is critical to the function of small single-celled tubes, of which the seamless tubular excretory canals of Caenorhabditis elegans provide a tractable genetic model. Mutations in several sets of genes exhibit the Exc phenotype, in which canal luminal growth is visibly altered. Here, a focused reverse genomic screen of genes highly expressed in the canals found 18 genes that significantly affect luminal outgrowth or diameter. These genes encode novel proteins as well as highly conserved proteins involved in processes including gene expression, cytoskeletal regulation, and vesicular and transmembrane transport. In addition, two genes act as suppressors on a pathway of conserved genes whose products mediate vesicle movement from early to recycling endosomes. The results provide new tools for understanding the integration of cytoplasmic structure and physiology in forming and maintaining the narrow diameter of single-cell tubules.en_US
dc.description.sponsorshipKU Graduate Research Fund #2301847en_US
dc.description.sponsorshipKU Graduate Research Fund #2144091en_US
dc.description.sponsorshipNIH NS0090945en_US
dc.description.sponsorshipNIH NS0095682en_US
dc.description.sponsorshipNIH NS0076063en_US
dc.description.sponsorshipNIH GM103638en_US
dc.description.sponsorshipNIH Office of Research Infrastructure Programs (P40 OD010440)en_US
dc.publisherGenetics Society of Americaen_US
dc.rightsCopyright © 2019 Al-Hashimi et al.en_US
dc.subjectLumen formationen_US
dc.subjectCharcot-Marie-Tooth Syndrome Type 4Hen_US
dc.titleNovel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegansen_US
kusw.kuauthorAl-Hashimi, Hikmat
kusw.kuauthorChiarelli, Travis
kusw.kuauthorLundquist, Erik A.
kusw.kuauthorBuechner, Matthew
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Copyright © 2019 Al-Hashimi et al.
Except where otherwise noted, this item's license is described as: Copyright © 2019 Al-Hashimi et al.