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dc.contributor.authorZhang, Albert
dc.contributor.authorAckley, Brian D.
dc.contributor.authorYan, Dong
dc.identifier.citationZhang, A., Ackley, B. D., & Yan, D. (2020). Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression. Cell reports, 30(12), 3981–3988.e3.
dc.descriptionThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en_US
dc.description.abstractVitamin B12 is known to play critical roles during the development and aging of the brain, and vitamin B12 deficiency has been linked to neurodevelopmental and degenerative disorders. However, the underlying molecular mechanisms of how vitamin B12 affects the development and maintenance of the nervous system are still unclear. Here, we report that vitamin B12 can regulate glial migration and synapse formation through control of isoform-specific expression of PTP-3/LAR PRTP (leukocyte-common antigen-related receptor-type tyrosine-protein phosphatase). We found the uptake of diet-supplied vitamin B12 in the intestine to be critical for the expression of a long isoform of PTP-3 (PTP-3A) in neuronal and glial cells. The expression of PTP-3A cell autonomously regulates glial migration and synapse formation through interaction with an extracellular matrix protein NID-1/nidogen 1. Together, our findings demonstrate that isoform-specific regulation of PTP-3/ LAR PRTP expression is a key molecular mechanism that mediates vitamin-B12-dependent neuronal and glial development.en_US
dc.description.sponsorshipNIH P40 OD010440en_US
dc.description.sponsorshipHolland Trice Awardsen_US
dc.description.sponsorshipNIH R01 NS09417en_US
dc.description.sponsorshipNIH R01NS105638en_US
dc.publisherCell Pressen_US
dc.rights© 2020 The Author(s).en_US
dc.subjectC. elegansen_US
dc.subjectVitamin B12en_US
dc.subjectNeuronal developmenten_US
dc.subjectGlial developmenten_US
dc.subjectGlial migrationen_US
dc.subjectSynapse formationen_US
dc.titleVitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expressionen_US
kusw.kuauthorAckley, Brian D.
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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Except where otherwise noted, this item's license is described as: © 2020 The Author(s).