Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

Zimmerman, Matthew; McDonald, Stacey L.; Ho-Liang, Hsin-Pin; Porubsky, Patrick; Nguyen, Quyen; Pharr, Cameron W.; Perkowski, Andrew J.; Smith, Robert; Schoenen, Frank J.; Gold, Ben S.; Zhang, David; Nathan, Carl F.; Dartois, Véronique; Aubé, Jeffrey

dc.contributor.author	Zimmerman, Matthew
dc.contributor.author	McDonald, Stacey L.
dc.contributor.author	Ho-Liang, Hsin-Pin
dc.contributor.author	Porubsky, Patrick
dc.contributor.author	Nguyen, Quyen
dc.contributor.author	Pharr, Cameron W.
dc.contributor.author	Perkowski, Andrew J.
dc.contributor.author	Smith, Robert
dc.contributor.author	Schoenen, Frank J.
dc.contributor.author	Gold, Ben S.
dc.contributor.author	Zhang, David
dc.contributor.author	Nathan, Carl F.
dc.contributor.author	Dartois, Véronique
dc.contributor.author	Aubé, Jeffrey
dc.date.accessioned	2020-06-18T20:17:41Z
dc.date.available	2020-06-18T20:17:41Z
dc.date.issued	2019-03-22
dc.identifier.citation	Zimmerman, M., McDonald, S. L., Ho-Liang, H. P., Porubsky, P., Nguyen, Q., Pharr, C. W., Perkowski, A. J., Smith, R., Schoenen, F. J., Gold, B. S., Zhang, D., Nathan, C. F., Dartois, V., & Aubé, J. (2019). Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma. The Journal of antibiotics, 72(6), 469–475. https://doi.org/10.1038/s41429-019-0167-y	en_US
dc.identifier.uri	http://hdl.handle.net/1808/30552
dc.description	This work is licensed under a Creative Commons Attribution 4.0 International License.	en_US
dc.description.abstract	A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.	en_US
dc.publisher	Springer Nature	en_US
dc.rights	© The Author(s) 2019.	en_US
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en_US
dc.title	Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma	en_US
dc.type	Article	en_US
kusw.kuauthor	Porubsky, Patrick
kusw.kuauthor	Nguyen, Quyen
kusw.kuauthor	Smith, Robert
kusw.kuauthor	Schoenen, Frank J.
kusw.kuauthor	Aubé, Jeffrey
kusw.kudepartment	Specialized Chemistry Center	en_US
dc.identifier.doi	10.1038/s41429-019-0167-y	en_US
dc.identifier.orcid	https://orcid.org/0000-0003-1049-5767	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC7255492	en_US
dc.rights.accessrights	openAccess	en_US

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