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dc.contributor.authorKurland, Meagan
dc.contributor.authorO’Meara, Bryn
dc.contributor.authorTucker, Dana K.
dc.contributor.authorAckley, Brian D.
dc.identifier.citationKurland, M., O'Meara, B., Tucker, D. K., & Ackley, B. D. (2020). The Hox Gene egl-5 Acts as a Terminal Selector for VD13 Development via Wnt Signaling. Journal of developmental biology, 8(1), 5.
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractNervous systems are comprised of diverse cell types that differ functionally and morphologically. During development, extrinsic signals, e.g., growth factors, can activate intrinsic programs, usually orchestrated by networks of transcription factors. Within that network, transcription factors that drive the specification of features specific to a limited number of cells are often referred to as terminal selectors. While we still have an incomplete view of how individual neurons within organisms become specified, reporters limited to a subset of neurons in a nervous system can facilitate the discovery of cell specification programs. We have identified a fluorescent reporter that labels VD13, the most posterior of the 19 inhibitory GABA (γ-amino butyric acid)-ergic motorneurons, and two additional neurons, LUAL and LUAR. Loss of function in multiple Wnt signaling genes resulted in an incompletely penetrant loss of the marker, selectively in VD13, but not the LUAs, even though other aspects of GABAergic specification in VD13 were normal. The posterior Hox gene, egl-5, was necessary for expression of our marker in VD13, and ectopic expression of egl-5 in more anterior GABAergic neurons induced expression of the marker. These results suggest egl-5 is a terminal selector of VD13, subsequent to GABAergic specification.en_US
dc.rights© 2020 by the authors.en_US
dc.subjectWnt signalingen_US
dc.subjectHox genesen_US
dc.subjectNeuron specificationen_US
dc.subjectAxon outgrowthen_US
dc.titleThe Hox Gene egl-5 Acts as a Terminal Selector for VD13 Development via Wnt Signalingen_US
kusw.kuauthorKurland, Meagan
kusw.kuauthorO’Meara, Bryn
kusw.kuauthorAckley, Brian D.
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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