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Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
dc.contributor.author | Wu, Xiaoqing | |
dc.contributor.author | Gardashova, Gulhumay | |
dc.contributor.author | Lan, Lan | |
dc.contributor.author | Han, Shuang | |
dc.contributor.author | Zhong, Cuncong | |
dc.contributor.author | Marquez, Rebecca T. | |
dc.contributor.author | Wei, Lanjing | |
dc.contributor.author | Wood, Spencer | |
dc.contributor.author | Roy, Sudeshna | |
dc.contributor.author | Gowthaman, Ragul | |
dc.contributor.author | Karanicolas, John | |
dc.contributor.author | Gao, Fei P. | |
dc.contributor.author | Dixon, Dan A. | |
dc.contributor.author | Welch, Danny R. | |
dc.contributor.author | Li, Ling | |
dc.contributor.author | Ji, Min | |
dc.contributor.author | Aubé, Jeffrey | |
dc.contributor.author | Xu, Liang | |
dc.date.accessioned | 2020-06-17T20:24:05Z | |
dc.date.available | 2020-06-17T20:24:05Z | |
dc.date.issued | 2020-04-24 | |
dc.identifier.citation | Wu, X., Gardashova, G., Lan, L., Han, S., Zhong, C., Marquez, R. T., Wei, L., Wood, S., Roy, S., Gowthaman, R., Karanicolas, J., Gao, F. P., Dixon, D. A., Welch, D. R., Li, L., Ji, M., Aubé, J., & Xu, L. (2020). Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis. Communications biology, 3(1), 193. https://doi.org/10.1038/s42003-020-0933-1 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/30539 | |
dc.description | This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.description.abstract | Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, and cytokines that support major tumor hallmarks including invasion and metastasis. Here, we report a HuR inhibitor KH-3, which potently suppresses breast cancer cell growth and invasion. Furthermore, KH-3 inhibits breast cancer experimental lung metastasis, improves mouse survival, and reduces orthotopic tumor growth. Mechanistically, we identify FOXQ1 as a direct target of HuR. KH-3 disrupts HuR–FOXQ1 mRNA interaction, leading to inhibition of breast cancer invasion. Our study suggests that inhibiting HuR is a promising therapeutic strategy for lethal metastatic breast cancer. | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | © The Author(s) 2020. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Drug development | en_US |
dc.subject | Target validation | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Metastasis | en_US |
dc.title | Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Wu, Xiaoqing | |
kusw.kuauthor | Gardashova, Gulhumay | |
kusw.kuauthor | Lan, Lan | |
kusw.kuauthor | Han, Shuang | |
kusw.kuauthor | Zhong, Cuncong | |
kusw.kuauthor | Marquez, Rebecca T. | |
kusw.kuauthor | Wei, Lanjingv | |
kusw.kuauthor | Gowthaman, Ragul | |
kusw.kuauthor | Gao, Fei P. | |
kusw.kuauthor | Dixon, Dan A. | |
kusw.kuauthor | Xu, Liang | |
kusw.kudepartment | Molecular Biosciences | en_US |
kusw.kudepartment | Electrical Engineering and Computer Science | en_US |
kusw.kudepartment | Bioengineering | en_US |
kusw.kudepartment | Center for Computational Biology | en_US |
kusw.kudepartment | Protein Production Group, NIH COBRE in Protein Structure and Function | en_US |
dc.identifier.doi | 10.1038/s42003-020-0933-1 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-2076-4107 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-2567-1893 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-8045-7654 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-8777-082X | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-0237-4156 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-0008-6401 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-0300-726X | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-9741-9390 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-5631-4365 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-1951-4947 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-8468-7772 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-1049-5767 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-9196-4232 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC7181695 | en_US |
dc.rights.accessrights | openAccess | en_US |