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dc.contributor.authorWu, Xiaoqing
dc.contributor.authorGardashova, Gulhumay
dc.contributor.authorLan, Lan
dc.contributor.authorHan, Shuang
dc.contributor.authorZhong, Cuncong
dc.contributor.authorMarquez, Rebecca T.
dc.contributor.authorWei, Lanjing
dc.contributor.authorWood, Spencer
dc.contributor.authorRoy, Sudeshna
dc.contributor.authorGowthaman, Ragul
dc.contributor.authorKaranicolas, John
dc.contributor.authorGao, Fei P.
dc.contributor.authorDixon, Dan A.
dc.contributor.authorWelch, Danny R.
dc.contributor.authorLi, Ling
dc.contributor.authorJi, Min
dc.contributor.authorAubé, Jeffrey
dc.contributor.authorXu, Liang
dc.date.accessioned2020-06-17T20:24:05Z
dc.date.available2020-06-17T20:24:05Z
dc.date.issued2020-04-24
dc.identifier.citationWu, X., Gardashova, G., Lan, L., Han, S., Zhong, C., Marquez, R. T., Wei, L., Wood, S., Roy, S., Gowthaman, R., Karanicolas, J., Gao, F. P., Dixon, D. A., Welch, D. R., Li, L., Ji, M., Aubé, J., & Xu, L. (2020). Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis. Communications biology, 3(1), 193. https://doi.org/10.1038/s42003-020-0933-1en_US
dc.identifier.urihttp://hdl.handle.net/1808/30539
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractPatients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, and cytokines that support major tumor hallmarks including invasion and metastasis. Here, we report a HuR inhibitor KH-3, which potently suppresses breast cancer cell growth and invasion. Furthermore, KH-3 inhibits breast cancer experimental lung metastasis, improves mouse survival, and reduces orthotopic tumor growth. Mechanistically, we identify FOXQ1 as a direct target of HuR. KH-3 disrupts HuR–FOXQ1 mRNA interaction, leading to inhibition of breast cancer invasion. Our study suggests that inhibiting HuR is a promising therapeutic strategy for lethal metastatic breast cancer.en_US
dc.publisherNature Researchen_US
dc.rights© The Author(s) 2020.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectDrug developmenten_US
dc.subjectTarget validationen_US
dc.subjectBreast canceren_US
dc.subjectMetastasisen_US
dc.titleTargeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasisen_US
dc.typeArticleen_US
kusw.kuauthorWu, Xiaoqing
kusw.kuauthorGardashova, Gulhumay
kusw.kuauthorLan, Lan
kusw.kuauthorHan, Shuang
kusw.kuauthorZhong, Cuncong
kusw.kuauthorMarquez, Rebecca T.
kusw.kuauthorWei, Lanjingv
kusw.kuauthorGowthaman, Ragul
kusw.kuauthorGao, Fei P.
kusw.kuauthorDixon, Dan A.
kusw.kuauthorXu, Liang
kusw.kudepartmentMolecular Biosciencesen_US
kusw.kudepartmentElectrical Engineering and Computer Scienceen_US
kusw.kudepartmentBioengineeringen_US
kusw.kudepartmentCenter for Computational Biologyen_US
kusw.kudepartmentProtein Production Group, NIH COBRE in Protein Structure and Functionen_US
dc.identifier.doi10.1038/s42003-020-0933-1en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2076-4107en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-2567-1893en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8045-7654en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8777-082Xen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0237-4156en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0008-6401en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0300-726Xen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9741-9390en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5631-4365en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1951-4947en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8468-7772en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1049-5767en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9196-4232en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7181695en_US
dc.rights.accessrightsopenAccessen_US


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© The Author(s) 2020.
Except where otherwise noted, this item's license is described as: © The Author(s) 2020.