Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

Schöneich, Christian

dc.contributor.author	Schöneich, Christian
dc.date.accessioned	2020-06-12T19:49:58Z
dc.date.available	2020-06-12T19:49:58Z
dc.date.issued	2019-11-28
dc.identifier.citation	Schöneich C. (2019). Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins. Molecules (Basel, Switzerland), 24(23), 4357. https://doi.org/10.3390/molecules24234357	en_US
dc.identifier.uri	http://hdl.handle.net/1808/30463
dc.description	This work is licensed under a Creative Commons Attribution 4.0 International License.	en_US
dc.description.abstract	Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies.	en_US
dc.publisher	MDPI	en_US
dc.rights	© 2019 by the author.	en_US
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en_US
dc.subject	Protein stability	en_US
dc.subject	Therapeutic proteins	en_US
dc.subject	Thiyl radicals	en_US
dc.subject	Oxidation	en_US
dc.subject	Fragmentation	en_US
dc.subject	Cross-link	en_US
dc.title	Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins	en_US
dc.type	Article	en_US
kusw.kuauthor	Schöneich, Christian
kusw.kudepartment	Pharmaceutical Chemistry	en_US
dc.identifier.doi	10.3390/molecules24234357	en_US
dc.identifier.orcid	https://orcid.org/0000-0001-5082-8672	en_US
kusw.oaversion	Scholarly/refereed, publisher version	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC6930596	en_US
dc.rights.accessrights	openAccess	en_US

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