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Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
dc.contributor.author | Schöneich, Christian | |
dc.date.accessioned | 2020-06-12T19:49:58Z | |
dc.date.available | 2020-06-12T19:49:58Z | |
dc.date.issued | 2019-11-28 | |
dc.identifier.citation | Schöneich C. (2019). Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins. Molecules (Basel, Switzerland), 24(23), 4357. https://doi.org/10.3390/molecules24234357 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/30463 | |
dc.description | This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.description.abstract | Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies. | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2019 by the author. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Protein stability | en_US |
dc.subject | Therapeutic proteins | en_US |
dc.subject | Thiyl radicals | en_US |
dc.subject | Oxidation | en_US |
dc.subject | Fragmentation | en_US |
dc.subject | Cross-link | en_US |
dc.title | Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Schöneich, Christian | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.3390/molecules24234357 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-5082-8672 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC6930596 | en_US |
dc.rights.accessrights | openAccess | en_US |