Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
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Issue Date
2019-11-28Author
Schöneich, Christian
Publisher
MDPI
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2019 by the author.
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Show full item recordAbstract
Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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Citation
Schöneich C. (2019). Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins. Molecules (Basel, Switzerland), 24(23), 4357. https://doi.org/10.3390/molecules24234357
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