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dc.contributor.authorLea, Jenna Kay
dc.contributor.authorUnckless, Robert L.
dc.identifier.citationLea, J. K., & Unckless, R. L. (2019). An assessment of the immune costs associated with meiotic drive elements in Drosophila. Proceedings. Biological sciences, 286(1911), 20191534.
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractMost organisms are constantly adapting to pathogens and parasites that exploit their host for their own benefit. Less studied, but perhaps more ubiquitous, are intragenomic parasites or selfish genetic elements. These include transposable elements, selfish B chromosomes and meiotic drivers that promote their own replication without regard to fitness effects on hosts. Therefore, intragenomic parasites are also a constant evolutionary pressure on hosts. Gamete-killing meiotic drive elements are often associated with large chromosomal inversions that reduce recombination between the drive and wild-type chromosomes. This reduced recombination is thought to reduce the efficacy of selection on the drive chromosome and allow for the accumulation of deleterious mutations. We tested whether gamete-killing meiotic drive chromosomes were associated with reduced immune defence against two bacterial pathogens in three species of Drosophila. We found little evidence of reduced immune defence in lines with meiotic drive. One line carrying the Drosophila melanogaster autosomal Segregation Distorter did show reduced defence, but we were unable to attribute that reduced defence to either genotype or immune gene expression differences. Our results suggest that though gamete-killing meiotic drive chromosomes probably accumulate deleterious mutations, those mutations do not result in reduced capacity for immune defence.en_US
dc.publisherThe Royal Societyen_US
dc.rights© 2019 The Authors.en_US
dc.subjectSegregation distorteren_US
dc.titleAn assessment of the immune costs associated with meiotic drive elements in Drosophilaen_US
kusw.kuauthorLea, Jenna Kay
kusw.kuauthorUnckless, Robert L.
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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© 2019 The Authors.
Except where otherwise noted, this item's license is described as: © 2019 The Authors.