Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants
dc.contributor.author | Wisdom, Cate | |
dc.contributor.author | Chen, Casey | |
dc.contributor.author | Yuca, Esra | |
dc.contributor.author | Zhou, Yan | |
dc.contributor.author | Tamerler, Candan | |
dc.contributor.author | Snead, Malcolm L. | |
dc.date.accessioned | 2019-11-07T22:04:46Z | |
dc.date.available | 2019-11-07T22:04:46Z | |
dc.date.issued | 2019-01-01 | |
dc.identifier.citation | Wisdom, C., Chen, C., Yuca, E., Zhou, Y., Tamerler, C., & Snead, M. L. (2019). Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants. JOM (Warrendale, Pa. : 1989), 71(4), 1271–1280. doi:10.1007/s11837-019-03334-w | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/29723 | |
dc.description | This is a post-peer-review, pre-copyedit version of an article published in JOM Journal of the Minerals, Metals and Materials Society. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11837-019-03334-w. | en_US |
dc.description.abstract | The rising use of titanium dental implants has increased the prevalence of peri-implant disease that shortens their useful life. A growing view of peri-implant disease suggests that plaque accumulation and microbiome dysbiogenesis trigger a host immune inflammatory response that destroys soft and hard tissues supporting the implant. The incidence of peri-implant disease is difficult to estimate, but with over 3 million implants placed in the USA alone, and the market growing by 500,000 implants/year, such extensive use demands additional interceptive approaches. We report a water-based, nonsurgical approach to address peri-implant disease using a bifunctional peptide film, which can be applied during initial implant placement and later reapplied to existing implants to reduce bacterial growth. Bifunctional peptides are based upon a titanium binding peptide (TiBP) optimally linked by a spacer peptide to an antimicrobial peptide (AMP). We show herein that dental implant surfaces covered with a bifunctional peptide film kill bacteria. Further, using a simple protocol for cleaning implant surfaces fouled by bacteria, the surface can be effectively recoated with TiBP-AMP to regain an antimicrobial state. Fouling, cleansing, and rebinding was confirmed for up to four cycles with minimal loss of binding efficacy. After fouling, rebinding with a water-based peptide film extends control over the oral microbiome composition, providing a novel nonsurgical treatment for dental implants. | en_US |
dc.publisher | Springer Verlag | en_US |
dc.rights | © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Wisdom, Cate | |
kusw.kuauthor | Yuca, Esra | |
kusw.kuauthor | Tamerler, Candan | |
kusw.kudepartment | Bioengineering Research Center | en_US |
kusw.kudepartment | Mechanical Engineering | en_US |
dc.identifier.doi | 10.1007/s11837-019-03334-w | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-4496-6478 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC6550465 | en_US |
dc.rights.accessrights | OpenAccess | en_US |
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Except where otherwise noted, this item's license is described as: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.