Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain
dc.contributor.author | Clarke, Duncan J. | |
dc.contributor.author | Azuma, Yoshiaki | |
dc.date.accessioned | 2018-10-04T16:18:35Z | |
dc.date.available | 2018-10-04T16:18:35Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Clarke DJ, Azuma Y. Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain. International Journal of Molecular Sciences. 2017; 18(11):2438 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/26775 | |
dc.description.abstract | DNA Topoisomerase II (Topo II ) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for numerous cellular processes. However, the enzyme also possesses a C-terminal domain (CTD) that is largely dispensable for the strand passage reaction but is nevertheless important for the fidelity of cell division. Recent studies have expanded our understanding of the roles of the Topo II CTD, in particular in mitotic mechanisms where the CTD is modified by Small Ubiquitin-like Modifier (SUMO), which in turn provides binding sites for key regulators of mitosis. | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Topoisomerase II | en_US |
dc.subject | SUMO | en_US |
dc.subject | C-terminal domain | en_US |
dc.subject | Mitosis | en_US |
dc.subject | Aurora B | en_US |
dc.subject | Haspin | en_US |
dc.subject | Claspin | en_US |
dc.subject | Metaphase checkpoint | en_US |
dc.title | Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Azuma, Yoshiaki | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | https://doi.org/10.3390/ijms18112438 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).