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dc.contributor.authorClarke, Duncan J.
dc.contributor.authorAzuma, Yoshiaki
dc.date.accessioned2018-10-04T16:18:35Z
dc.date.available2018-10-04T16:18:35Z
dc.date.issued2017
dc.identifier.citationClarke DJ, Azuma Y. Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain. International Journal of Molecular Sciences. 2017; 18(11):2438en_US
dc.identifier.urihttp://hdl.handle.net/1808/26775
dc.description.abstractDNA Topoisomerase II (Topo II ) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for numerous cellular processes. However, the enzyme also possesses a C-terminal domain (CTD) that is largely dispensable for the strand passage reaction but is nevertheless important for the fidelity of cell division. Recent studies have expanded our understanding of the roles of the Topo II CTD, in particular in mitotic mechanisms where the CTD is modified by Small Ubiquitin-like Modifier (SUMO), which in turn provides binding sites for key regulators of mitosis.en_US
dc.publisherMDPIen_US
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectTopoisomerase IIen_US
dc.subjectSUMOen_US
dc.subjectC-terminal domainen_US
dc.subjectMitosisen_US
dc.subjectAurora Ben_US
dc.subjectHaspinen_US
dc.subjectClaspinen_US
dc.subjectMetaphase checkpointen_US
dc.titleNon-Catalytic Roles of the Topoisomerase IIα C-Terminal Domainen_US
dc.typeArticleen_US
kusw.kuauthorAzuma, Yoshiaki
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doihttps://doi.org/10.3390/ijms18112438en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccessen_US


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© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).