Photocatalytic Aminodecarboxylation of Carboxylic Acids

Lang, Simon Bouyea; Cartwright, Kaitie C.; Welter, Richard S.; Locascio, Theresa M.; Tunge, Jon A.

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Issue Date

2016-07

Author

Lang, Simon Bouyea

Cartwright, Kaitie C.

Welter, Richard S.

Locascio, Theresa M.

Tunge, Jon A.

Publisher

Wiley

Type

Article

Article Version

Scholarly/refereed, publisher version

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Abstract

Aminodecarboxylation of unactivated alkyl carboxylic acids has been accomplished utilizing an organic photocatalyst. This operationally simple reaction utilizes readily available carboxylic acids to chemoselectively generate reactive alkyl intermediates that are not accessible via conventional two-electron pathways. The organic radical intermediates are efficiently trapped with electrophilic diazo compounds to provide aminated alkanes.

Citation

Lang, S. B., Cartwright, K. C., Welter, R. S., Locascio, T. M., & Tunge, J. A. (2016). Photocatalytic Aminodecarboxylation of Carboxylic Acids. European Journal of Organic Chemistry, 2016(20), 3331–3334. http://doi.org/10.1002/ejoc.201600620

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