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dc.contributor.authorHasan, Anwarul
dc.contributor.authorWaters, Renae
dc.contributor.authorRoula, Boustany
dc.contributor.authorDana, Rahbani
dc.contributor.authorYara, Seif
dc.contributor.authorAlexandre, Toubia
dc.contributor.authorPaul, Arghya
dc.date.accessioned2017-06-20T19:26:01Z
dc.date.available2017-06-20T19:26:01Z
dc.date.issued2016-03-08
dc.identifier.citationHasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci., 16: 958–977. doi:10.1002/mabi.201500396en_US
dc.identifier.urihttp://hdl.handle.net/1808/24562
dc.descriptionThis is the peer reviewed version of the following article: Hasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci., 16: 958–977. doi:10.1002/mabi.201500396, which has been published in final form at http://doi.org/10.1002/mabi.201500396. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.description.abstractCardiovascular disease is a leading cause of death worldwide. Since adult cardiac cells are limited in their proliferation, cardiac tissue with dead or damaged cardiac cells downstream of the occluded vessel does not regenerate after myocardial infarction. The cardiac tissue is then replaced with nonfunctional fibrotic scar tissue rather than new cardiac cells, which leaves the heart weak. The limited proliferation ability of host cardiac cells has motivated investigators to research the potential cardiac regenerative ability of stem cells. Considerable progress has been made in this endeavor. However, the optimum type of stem cells along with the most suitable matrix-material and cellular microenvironmental cues are yet to be identified or agreed upon. This review presents an overview of various types of biofunctional materials and biomaterial matrices, which in combination with stem cells, have shown promises for cardiac tissue replacement and reinforcement. Engineered biomaterials also have applications in cardiac tissue engineering, in which tissue constructs are developed in vitro by combining stem cells and biomaterial scaffolds for drug screening or eventual implantation. This review highlights the benefits of using biomaterials in conjunction with stem cells to repair damaged myocardium and give a brief description of the properties of these biomaterials that make them such valuable tools to the field.en_US
dc.publisherWileyen_US
dc.subjectAngiogenesisen_US
dc.subjectHydrogelen_US
dc.subjectMyocardial infarctionen_US
dc.subjectNanomedicineen_US
dc.subjectStem cellsen_US
dc.titleEngineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapyen_US
dc.typeArticleen_US
kusw.kuauthorWaters, Renae
kusw.kuauthorPaul, Arghya
kusw.kudepartmentChemical and Petroleum Engineeringen_US
dc.identifier.doi10.1002/mabi.201500396en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4931991en_US
dc.rights.accessrightsopenAccess


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