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    Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy

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    Waters_2016.pdf (1.852Mb)
    Issue Date
    2016-03-08
    Author
    Hasan, Anwarul
    Waters, Renae
    Roula, Boustany
    Dana, Rahbani
    Yara, Seif
    Alexandre, Toubia
    Paul, Arghya
    Publisher
    Wiley
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Cardiovascular disease is a leading cause of death worldwide. Since adult cardiac cells are limited in their proliferation, cardiac tissue with dead or damaged cardiac cells downstream of the occluded vessel does not regenerate after myocardial infarction. The cardiac tissue is then replaced with nonfunctional fibrotic scar tissue rather than new cardiac cells, which leaves the heart weak. The limited proliferation ability of host cardiac cells has motivated investigators to research the potential cardiac regenerative ability of stem cells. Considerable progress has been made in this endeavor. However, the optimum type of stem cells along with the most suitable matrix-material and cellular microenvironmental cues are yet to be identified or agreed upon. This review presents an overview of various types of biofunctional materials and biomaterial matrices, which in combination with stem cells, have shown promises for cardiac tissue replacement and reinforcement. Engineered biomaterials also have applications in cardiac tissue engineering, in which tissue constructs are developed in vitro by combining stem cells and biomaterial scaffolds for drug screening or eventual implantation. This review highlights the benefits of using biomaterials in conjunction with stem cells to repair damaged myocardium and give a brief description of the properties of these biomaterials that make them such valuable tools to the field.
    Description
    This is the peer reviewed version of the following article: Hasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci., 16: 958–977. doi:10.1002/mabi.201500396, which has been published in final form at http://doi.org/10.1002/mabi.201500396. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    URI
    http://hdl.handle.net/1808/24562
    DOI
    https://doi.org/10.1002/mabi.201500396
    Collections
    • Chemical & Petroleum Engineering Scholarly Works [173]
    Citation
    Hasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci., 16: 958–977. doi:10.1002/mabi.201500396

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    KU Libraries
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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