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dc.contributor.authorYucesoy, Deniz Tanil
dc.contributor.authorHnilova, Marketa
dc.contributor.authorBoone, Kyle W.
dc.contributor.authorArnold, Paul M.
dc.contributor.authorSnead, Malcolm L.
dc.contributor.authorTamerler, Candan
dc.date.accessioned2017-06-20T16:02:24Z
dc.date.available2017-06-20T16:02:24Z
dc.date.issued2015-04
dc.identifier.citationYucesoy, D. T., Hnilova, M., Boone, K., Arnold, P. M., Snead, M. L., & Tamerler, C. (2015). Chimeric peptides as implant functionalization agents for titanium alloy implants with antimicrobial properties. JOM (Warrendale, Pa. : 1989), 67(4), 754–766. http://doi.org/10.1007/s11837-015-1350-7en_US
dc.identifier.urihttp://hdl.handle.net/1808/24552
dc.descriptionThe final publication is available at Springer via http://dx.doi.org/10.1007/s11837-015-1350-7.
dc.description.abstractImplant-associated infections can have severe effects on the longevity of implant devices and they also represent a major cause of implant failures. Treating these infections associated with implants by antibiotics is not always an effective strategy due to poor penetration rates of antibiotics into biofilms. Additionally, emerging antibiotic resistance poses serious concerns. There is an urge to develop effective antibacterial surfaces that prevent bacterial adhesion and proliferation. A novel class of bacterial therapeutic agents, known as antimicrobial peptides (AMP’s), are receiving increasing attention as an unconventional option to treat septic infection, partly due to their capacity to stimulate innate immune responses and for the difficulty of microorganisms to develop resistance towards them. While host- and bacterial- cells compete in determining the ultimate fate of the implant, functionalization of implant surfaces with antimicrobial peptides can shift the balance and prevent implant infections. In the present study, we developed a novel chimeric peptide to functionalize the implant material surface. The chimeric peptide simultaneously presents two functionalities, with one domain binding to a titanium alloy implant surface through a titanium-binding domain while the other domain displays an antimicrobial property. This approach gains strength through control over the bio-material interfaces, a property built upon molecular recognition and self-assembly through a titanium alloy binding domain in the chimeric peptide. The efficiency of chimeric peptide both in-solution and absorbed onto titanium alloy surface was evaluated in vitro against three common human host infectious bacteria, S. mutans, S. epidermidis, and E. coli. In biological interactions such as occurs on implants, it is the surface and the interface that dictate the ultimate outcome. Controlling the implant surface by creating an interface composed chimeric peptides may therefore open up new possibilities to cover the implant site and tailor it to a desirable bioactivity.en_US
dc.publisherSpringer Verlagen_US
dc.rights© The Minerals, Metals & Materials Society 2015en_US
dc.subjectAntimicrobial coatingsen_US
dc.subjectBio-material interfacesen_US
dc.subjectBiological surface functionalizationen_US
dc.subjectBiointerfaceen_US
dc.subjectBioactivityen_US
dc.subjectInfection-free implantsen_US
dc.titleChimeric peptides as implant functionalization agents for titanium alloy implants with antimicrobial propertiesen_US
dc.typeArticleen_US
kusw.kuauthorBoone, Kyle
kusw.kuauthorTamerler, Candan
kusw.kudepartmentBioengineeringen_US
dc.identifier.doi10.1007/s11837-015-1350-7en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4450091en_US
dc.rights.accessrightsopenAccess


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