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    Chimeric peptides as implant functionalization agents for titanium alloy implants with antimicrobial properties

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    Boone_2015.pdf (1.792Mb)
    Issue Date
    2015-04
    Author
    Yucesoy, Deniz Tanil
    Hnilova, Marketa
    Boone, Kyle W.
    Arnold, Paul M.
    Snead, Malcolm L.
    Tamerler, Candan
    Publisher
    Springer Verlag
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    © The Minerals, Metals & Materials Society 2015
    Metadata
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    Abstract
    Implant-associated infections can have severe effects on the longevity of implant devices and they also represent a major cause of implant failures. Treating these infections associated with implants by antibiotics is not always an effective strategy due to poor penetration rates of antibiotics into biofilms. Additionally, emerging antibiotic resistance poses serious concerns. There is an urge to develop effective antibacterial surfaces that prevent bacterial adhesion and proliferation. A novel class of bacterial therapeutic agents, known as antimicrobial peptides (AMP’s), are receiving increasing attention as an unconventional option to treat septic infection, partly due to their capacity to stimulate innate immune responses and for the difficulty of microorganisms to develop resistance towards them. While host- and bacterial- cells compete in determining the ultimate fate of the implant, functionalization of implant surfaces with antimicrobial peptides can shift the balance and prevent implant infections. In the present study, we developed a novel chimeric peptide to functionalize the implant material surface. The chimeric peptide simultaneously presents two functionalities, with one domain binding to a titanium alloy implant surface through a titanium-binding domain while the other domain displays an antimicrobial property. This approach gains strength through control over the bio-material interfaces, a property built upon molecular recognition and self-assembly through a titanium alloy binding domain in the chimeric peptide. The efficiency of chimeric peptide both in-solution and absorbed onto titanium alloy surface was evaluated in vitro against three common human host infectious bacteria, S. mutans, S. epidermidis, and E. coli. In biological interactions such as occurs on implants, it is the surface and the interface that dictate the ultimate outcome. Controlling the implant surface by creating an interface composed chimeric peptides may therefore open up new possibilities to cover the implant site and tailor it to a desirable bioactivity.
    Description
    The final publication is available at Springer via http://dx.doi.org/10.1007/s11837-015-1350-7.
    URI
    http://hdl.handle.net/1808/24552
    DOI
    https://doi.org/10.1007/s11837-015-1350-7
    Collections
    • Bioengineering Program Scholarly Works [140]
    Citation
    Yucesoy, D. T., Hnilova, M., Boone, K., Arnold, P. M., Snead, M. L., & Tamerler, C. (2015). Chimeric peptides as implant functionalization agents for titanium alloy implants with antimicrobial properties. JOM (Warrendale, Pa. : 1989), 67(4), 754–766. http://doi.org/10.1007/s11837-015-1350-7

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    KU Libraries
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    785-864-8983

    KU Libraries
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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