Protein Structure Prediction: Is It Useful?
|dc.identifier.citation||Zhang, Y. (2009). Protein Structure Prediction: Is It Useful? Current Opinion in Structural Biology, 19(2), 145–155. http://doi.org/10.1016/j.sbi.2009.02.005||en_US|
|dc.description.abstract||Computationally predicted three-dimensional structure of protein molecules has demonstrated the usefulness in many areas of biomedicine, ranging from approximate family assignments to precise drug screening. For nearly 40 years, however, the accuracy of the predicted models has been dictated by the availability of close structural templates. Progress has recently been achieved in refining low-resolution models closer to the native ones; this has been made possible by combining knowledge-based information from multiple sources of structural templates as well as by improving the energy funnel of physics-based force fields. Unfortunately, there has been no essential progress in the development of techniques for detecting remotely homologous templates and for predicting novel protein structures.||en_US|
|dc.rights||This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.||en_US|
|dc.title||Protein Structure Prediction: Is It Useful?||en_US|
|kusw.oanotes||Per SHERPA/RoMEO 6/8/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions: Authors pre-print on any website, including arXiv and RePEC Author's post-print on author's personal website immediately Author's post-print on open access repository after an embargo period of between 12 months and 48 months Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months Author's post-print may be used to update arXiv and RepEC Publisher's version/PDF cannot be used Must link to publisher version with DOI Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License||en_US|
|kusw.oaversion||Scholarly/refereed, author accepted manuscript||en_US|
|kusw.oapolicy||This item meets KU Open Access policy criteria.||en_US|
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