Show simple item record

dc.contributor.authorSatyanarayanajois, Seetharama D.
dc.contributor.authorBüyüktimkin, Barlas
dc.contributor.authorGokhale, Ameya
dc.contributor.authorRonald, Sharon
dc.contributor.authorSiahaan, Teruna J.
dc.contributor.authorLatendresse, John R.
dc.date.accessioned2017-05-31T21:13:47Z
dc.date.available2017-05-31T21:13:47Z
dc.date.issued2010-09-01
dc.identifier.citationSatyanarayanajois, S. D., Büyüktimkin, B., Gokhale, A., Ronald, S., Siahaan, T. J. and Latendresse, J. R. (2010), A Peptide from the Beta-strand Region of CD2 Protein that Inhibits Cell Adhesion and Suppresses Arthritis in a Mouse Model. Chemical Biology & Drug Design, 76: 234–244. doi:10.1111/j.1747-0285.2010.01001.xen_US
dc.identifier.urihttp://hdl.handle.net/1808/24325
dc.descriptionThis is the peer reviewed version of the following article: Satyanarayanajois, S. D., Büyüktimkin, B., Gokhale, A., Ronald, S., Siahaan, T. J. and Latendresse, J. R. (2010), A Peptide from the Beta-strand Region of CD2 Protein that Inhibits Cell Adhesion and Suppresses Arthritis in a Mouse Model. Chemical Biology & Drug Design, 76: 234–244. doi:10.1111/j.1747-0285.2010.01001.x, which has been published in final form at http://doi.org/10.1111/j.1747-0285.2010.01001.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.description.abstractCell adhesion molecules play a central role at every step of the immune response. The function of leukocytes can be regulated by modulating adhesion interactions between cell adhesion molecules to develop therapeutic agents against autoimmune diseases. Among the different cell adhesion molecules that participate in the immunological response, CD2 and its ligand CD58 (LFA-3) are two of the best-characterized adhesion molecules mediating the immune response. To modulate the cell adhesion interaction, peptides were designed from the discontinuous epitopes of the β-strand region of CD2 protein. The two strands were linked by a peptide bond. β-Strands in the peptides were nucleated by inserting a β-sheet-inducing Pro-Gly sequence with key amino acid sequences from CD2 protein that binds to CD58. Using a fluorescence assay, peptides that exhibited potential inhibitory activity in cell adhesion were evaluated for their ability to bind to CD58 protein. A model for peptide binding to CD58 protein was proposed based on docking studies. Administration of one of the peptides, P3 in collagen-induced arthritis (CIA) in the mouse model, indicated that peptide P3 was able to suppress rheumatoid arthritis in mice.en_US
dc.publisherWileyen_US
dc.subjectBeta hairpinen_US
dc.subjectCD2 peptides CD2en_US
dc.subjectCD58en_US
dc.subjectCell adhesionen_US
dc.subjectNMRen_US
dc.subjectImmunomodulationen_US
dc.subjectArthritis mouse modelen_US
dc.titleA Peptide from the Beta-strand Region of CD2 Protein that Inhibits Cell Adhesion and Suppresses Arthritis in a Mouse Modelen_US
dc.typeArticleen_US
kusw.kuauthorBüyüktimkin, Barlas
kusw.kuauthorSiahaan, Teruna J.
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1111/j.1747-0285.2010.01001.xen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3009390en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record