ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Rhesus macaque model of chronic opiate dependence and neuro-AIDS: longitudinal assessment of auditory brainstem responses and visual evoked potentials
dc.contributor.author | Riazi, Mariam | |
dc.contributor.author | Marcario, Joanne K. | |
dc.contributor.author | Samson, Frank K. | |
dc.contributor.author | Kenjale, Himanshu | |
dc.contributor.author | Adany, Istvan | |
dc.contributor.author | Staggs, Vincent | |
dc.contributor.author | Ledford, Emily | |
dc.contributor.author | Marquis, Janet | |
dc.contributor.author | Narayan, Opendra | |
dc.contributor.author | Cheney, Paul D. | |
dc.date.accessioned | 2017-05-24T17:40:21Z | |
dc.date.available | 2017-05-24T17:40:21Z | |
dc.date.issued | 2009-06 | |
dc.identifier.citation | Riazi, M., Marcario, J. K., Samson, F. K., Kenjale, H., Adany, I., Staggs, V., … Cheney, P. D. (2009). Rhesus macaque model of chronic opiate dependence and neuro-AIDS: longitudinal assessment of auditory brainstem responses and visual evoked potentials. Journal of Neuroimmune Pharmacology : The Official Journal of the Society on NeuroImmune Pharmacology, 4(2), 260–275. http://doi.org/10.1007/s11481-009-9149-3 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24298 | |
dc.description.abstract | Our work characterizes the effects of opiate (morphine) dependence on auditory brainstem and visual evoked responses in a rhesus macaque model of neuro-AIDS utilizing a chronic continuous drug delivery paradigm. The goal of this study was to clarify whether morphine is protective, or if it exacerbates simian immunodeficiency virus (SIV) related systemic and neurological disease. Our model employs a macrophage tropic CD4/CCR5 co-receptor virus, SIVmac239 (R71/E17), which crosses the blood brain barrier shortly after inoculation and closely mimics the natural disease course of human immunodeficiency virus (HIV) infection. The cohort was divided into 3 groups: morphine only, SIV only, and SIV + morphine. Evoked potential (EP) abnormalities in sub-clinically infected macaques were evident as early as eight weeks post-inoculation. Prolongations in EP latencies were observed in SIV-infected macaques across all modalities. Animals with the highest CSF viral loads and clinical disease showed more abnormalities than those with sub-clinical disease, confirming our previous work (Raymond et al, 1998, 1999, 2000). Although some differences were observed in auditory and visual evoked potentials in morphine treated compared to untreated SIV-infected animals, the effects were relatively small and not consistent across evoked potential type. However, morphine treated animals with subclinical disease had a clear tendency toward higher virus loads in peripheral and CNS tissues (Marcario et al., 2008) suggesting that if had been possible to follow all animals to end-stage disease, a clearer pattern of evoked potential abnormality might have emerged. | en_US |
dc.publisher | Springer Verlag | en_US |
dc.rights | © Springer Science + Business Media, LLC 2009 | en_US |
dc.subject | SIV | en_US |
dc.subject | Monkey | en_US |
dc.subject | Morphine | en_US |
dc.subject | Evoked potentials | en_US |
dc.subject | Opiates | en_US |
dc.subject | Neuro-AIDS | en_US |
dc.title | Rhesus macaque model of chronic opiate dependence and neuro-AIDS: longitudinal assessment of auditory brainstem responses and visual evoked potentials | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Staggs, Vincent | |
kusw.kuauthor | Ledford, Emily | |
kusw.kuauthor | Marquis, Janet | |
kusw.kudepartment | Life Span Institute | en_US |
dc.identifier.doi | 10.1007/s11481-009-9149-3 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC3713620 | en_US |
dc.rights.accessrights | openAccess |
Files in this item
This item appears in the following Collection(s)
-
Life Span Institute Scholarly Works [129]
This collection contains work by the faculty and researchers affiliated with the Life Span Institute.