Life Span Institute Scholarly Works
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Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers
(BMC, 2019-01-21)Background Individuals with premutation alleles of the fragile X mental retardation 1 (FMR1) gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS) during aging. Characterization of motor issues ... -
The Effects of Physical Activity on Learning Behaviors in Elementary School Children: A Randomized Controlled Trial
(Springer, 2017-07-17)Research in education and developmental psychology indicates that behavioral engagement in learning is a critical predictor of children’s academic success. In an effort to improve academic achievement, school administrators ... -
Resting-State Brain Network Dysfunctions Associated With Visuomotor Impairments in Autism Spectrum Disorder
(Frontiers Media, 2019-05-31)Background: Individuals with autism spectrum disorder (ASD) show elevated levels of motor variability that are associated with clinical outcomes. Cortical–cerebellar networks involved in visuomotor control have been ... -
Developmental Effects on Auditory Neural Oscillatory Synchronization Abnormalities in Autism Spectrum Disorder
(Frontiers Media, 2019-07-25)Previous studies have found alterations in 40 Hz oscillatory activity in response to auditory stimuli in adults with Autism Spectrum Disorder (ASD). The current study sought to examine the specificity and developmental ... -
Cerebellar-cortical function and connectivity during sensorimotor behavior in aging FMR1 gene premutation carriers
(Elsevier, 2020-07-02)Introduction Premutation carriers of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease characterized by motor, cognitive, and psychiatric decline as ... -
Striatal bases of temporal discounting in early adolescents
(Elsevier, 2020-05-11)Steeper rates of temporal discounting—the degree to which smaller-sooner (SS) rewards are preferred over larger-later (LL) ones—have been associated with impulsive and ill-advised behaviors in adolescence. Yet, the underlying ... -
Task and Participant Variables Predict Communication Complexity Scores (CCS): Closer Examination of the CCS
(American Association on Intellectual and Developmental Disabilities, 2019-11-01)Communication Complexity Scale (CCS) scores for 269 minimally verbal participants were examined to determine if communicator behavior and task and communicator characteristics were related to scores in a manner consistent ... -
Developmental trajectory of communication repair in children with Fragile X Syndrome
(SAGE Publications, 2020-02-27)Background and aims The development of communicative competence requires both language and social skills. The ability to repair following a communication breakdown is critical for continued conversational interchange and ... -
Postural control processes during standing and step initiation in autism spectrum disorder
(BMC, 2020-01-06)Background Individuals with autism spectrum disorder (ASD) show a reduced ability to maintain postural stability, though motor control mechanisms contributing to these issues and the extent to which they are associated ... -
Adapting the Diabetes Prevention Program for low and middle-income countries: protocol for a cluster randomised trial to evaluate ‘Lifestyle Africa’
(BMJ Publishing Group, 2019-11-11)Introduction Low and middle-income countries like South Africa are experiencing major increases in burden of non-communicable diseases such as diabetes and cardiovascular conditions. However, evidence-based interventions ... -
Precision Sensorimotor Control in Aging FMR1 Gene Premutation Carriers
(Frontiers Media, 2019-10-02)Background: Individuals with premutation alleles of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative condition affecting sensorimotor function. Information ... -
Maternal Vitamin D Status and Infant Infection
(MDPI, 2018-01-23)Maternal vitamin D status during pregnancy may modulate fetal immune system development and infant susceptibility to infections. Vitamin D deficiency is common during pregnancy, particularly among African American (AA) ... -
Assessing whether early attention of very preterm infants can be improved by an omega-3 long-chain polyunsaturated fatty acid intervention: a follow-up of a randomised controlled tria
(BMJ, 2018-05-26)Introduction Docosahexaenoic acid (DHA) accumulates in the frontal lobes (responsible for higher-order cognitive skills) of the fetal brain during the last trimester of pregnancy. Infants born preterm miss some of this ... -
Hyper-Palatable Foods: Development of a Quantitative Definition and Application to the US Food System Database
(Wiley, 2019-11-05)Objective: Extensive research has focused on hyper-palatable foods (HPF); however, HPF are defined using descriptive terms (e.g., fast foods, sweets), which are not standardized and lack specificity. The study purpose was ... -
Precision Sensorimotor Control in Aging FMR1 Gene Premutation Carriers
(Frontiers Media, 2019-10-02)Background: Individuals with premutation alleles of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative condition affecting sensorimotor function. Information ... -
Cortical and subcortical alterations associated with precision visuomotor behavior in individuals with autism spectrum disorder
(American Physiological Society, 2019-09-23)In addition to core deficits in social-communication abilities and repetitive behaviors and interests, many 2 patients with autism spectrum disorder (ASD) experience developmental comorbidities, including 3 sensorimotor ... -
Parents’ Perspectives on the Theoretical Domains Framework Elements Needed in a Pediatric Health Behavior App: A Crowdsourced Social Validity Study
(JMIR Publications, 2018-12-21)Background: Most pediatric studies do not include parent stakeholders in the design of the intervention itself and many pediatric mobile health (mHealth) interventions are not meaningfully disseminated after the trial ... -
Systematic Replication of the Effects of a Supplementary, Technology-Assisted, Storybook Intervention for Preschool Children with Weak Vocabulary and Comprehension Skills
(University of Chicago Press, 2016-06)In 2013, Spencer, Goldstein, Sherman, et al. reported the promising effects of a supplemental, technology-assisted, storybook intervention (Tier 2) containing embedded instruction targeting the oral language learning of ... -
Reduced habituation of auditory evoked potentials indicate cortical hyper-excitability in Fragile X Syndrome
(Nature Publishing Group, 2016-04-19)Sensory hypersensitivities are common, clinically distressing features of Fragile X Syndrome (FXS). Preclinical evidence suggests this abnormality may result from synaptic hyper-excitability in sensory systems. This model ... -
Postural orientation and equilibrium processes associated with increased postural sway in autism spectrum disorder (ASD)
(BioMed Central, 2016-11-25)Background: Increased postural sway has been repeatedly documented in children with autism spectrum disorder (ASD). Characterizing the control processes underlying this deficit, including postural orientation and equilibrium, ...
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