Life Span Institute Scholarly Works
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The Importance of Self-Determination to the Quality of Life of People with Intellectual Disability: A Perspective
(MDPI, 2020-09-29)There is both an intuitive and theoretical link between self-determination and quality of life for people with intellectual and developmental disabilities. Theoretically, definitions of self-determination have framed the ... -
Cerebellar Volumes and Sensorimotor Behavior in Autism Spectrum Disorder
(Frontiers Media, 2022-05-03)Background: Sensorimotor issues are common in autism spectrum disorder (ASD), though their neural bases are not well understood. The cerebellum is vital to sensorimotor control and reduced cerebellar volumes in ASD have ... -
Modeling individual development plans, mentoring support, and career preparedness relationships among Doctor of Philosophy (Ph.D.) trainees in the life sciences
(F1000Research, 2021-12-17)Background: As greater career development support for doctoral students and postdoctoral researchers has been emphasized, the individual development plan (IDP) has become a recommended mentoring tool. However, little is ... -
Visuomotor brain network activation and functional connectivity among individuals with autism spectrum disorder
(Wiley Open Access, 2021-10-30)Sensorimotor abnormalities are common in autism spectrum disorder (ASD) and predictive of functional outcomes, though their neural underpinnings remain poorly understood. Using functional magnetic resonance imaging, we ... -
A Reflection on Community Research and Action as an Evolving Practice
(Springer, 2021-11-12)Community research and action is an evolving field of practice with multiple influences. Its varied ways of knowing and doing reflect recombined elements from different disciplines, including behavioral science, community ... -
Developmental effects on sleep–wake patterns in infants receiving a cow’s milk-based infant formula with an added prebiotic blend: A Randomized Controlled Trial
(Springer Nature, 2020-07-02)Background Few studies have evaluated nutritive effects of prebiotics on infant behavior state, physiology, or metabolic status. Methods In this double-blind randomized study, infants (n = 161) received cow’s milk-based ... -
Weight status and associated comorbidities in children and adults with Down syndrome, autism spectrum disorder and intellectual and developmental disabilities
(Wiley, 2020-07-27)Background Little is known about body weight status and the association between body weight and common comorbidities in children and adults with Down syndrome (DS), autism spectrum disorder (ASD) and other intellectual ... -
Upper and Lower Limb Movement Kinematics in Aging FMR1 Gene Premutation Carriers
(MDPI, 2020-12-24)Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder associated with a premutation cytosine-guanine-guanine (CGG) trinucleotide repeat expansion of the FMR1 gene. FXTAS is estimated to be the ... -
iKanEat: Protocol for a randomized controlled trial of megestrol as a component of a pediatric tube weaning protocol
(BMC, 2021-02-27)Background Although tube feeding routinely saves the lives of children who do not eat by mouth, chronic tube feeding can be a burden to patients, caregivers, and families. Very few randomized trials exist regarding the ... -
Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome
(BMC, 2021-04-28)Background Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other ... -
Costs and Benefits of Native Language Similarity for Non-native Word Learning
(Frontiers Media, 2021-05-28)The present study examined the costs and benefits of native language similarity for non-native vocabulary learning. Because learning a second language (L2) is difficult, many learners start with easy words that look like ... -
Initial action output and feedback-guided motor behaviors in autism spectrum disorder
(BMC, 2021-07-10)Background Sensorimotor issues are common in autism spectrum disorder (ASD), related to core symptoms, and predictive of worse functional outcomes. Deficits in rapid behaviors supported primarily by feedforward mechanisms, ... -
Visual and somatosensory feedback mechanisms of precision manual motor control in autism spectrum disorder
(BMC, 2021-09-08)Background Individuals with autism spectrum disorder (ASD) show deficits processing sensory feedback to reactively adjust ongoing motor behaviors. Atypical reliance on visual and somatosensory feedback each have been ... -
Assessment of Characteristics of Capacity Among Breast Cancer Screening Facilities
(Springer, 2011-11-27)Use of mammograms to detect presence of breast cancer is influenced by many factors, including ability to access mammography services. Access to services is often affected by the capacity of mammography facilities to serve ... -
Genomic, Clinical, and Behavioral Characterization of 15q11.2 BP1-BP2 Deletion (Burnside-Butler) Syndrome in Five Families
(MDPI, 2021-02-07)The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most common cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. ... -
Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers
(BMC, 2019-01-21)Background Individuals with premutation alleles of the fragile X mental retardation 1 (FMR1) gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS) during aging. Characterization of motor issues ... -
The Effects of Physical Activity on Learning Behaviors in Elementary School Children: A Randomized Controlled Trial
(Springer, 2017-07-17)Research in education and developmental psychology indicates that behavioral engagement in learning is a critical predictor of children’s academic success. In an effort to improve academic achievement, school administrators ... -
Resting-State Brain Network Dysfunctions Associated With Visuomotor Impairments in Autism Spectrum Disorder
(Frontiers Media, 2019-05-31)Background: Individuals with autism spectrum disorder (ASD) show elevated levels of motor variability that are associated with clinical outcomes. Cortical–cerebellar networks involved in visuomotor control have been ... -
Developmental Effects on Auditory Neural Oscillatory Synchronization Abnormalities in Autism Spectrum Disorder
(Frontiers Media, 2019-07-25)Previous studies have found alterations in 40 Hz oscillatory activity in response to auditory stimuli in adults with Autism Spectrum Disorder (ASD). The current study sought to examine the specificity and developmental ... -
Cerebellar-cortical function and connectivity during sensorimotor behavior in aging FMR1 gene premutation carriers
(Elsevier, 2020-07-02)Introduction Premutation carriers of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease characterized by motor, cognitive, and psychiatric decline as ...
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