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SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides
dc.contributor.author | Rolfe, Alan | |
dc.contributor.author | Samarakoon, Thiwanka Bandara | |
dc.contributor.author | Klimberg, Sarra V. | |
dc.contributor.author | Brzozowski, Marek | |
dc.contributor.author | Neuenswander, Benjamin | |
dc.contributor.author | Lushington, Gerald H. | |
dc.contributor.author | Hanson, Paul R. | |
dc.date.accessioned | 2017-05-22T16:29:16Z | |
dc.date.available | 2017-05-22T16:29:16Z | |
dc.date.issued | 2010-11-08 | |
dc.identifier.citation | Rolfe, A., Samarakoon, T. B., Klimberg, S. V., Brzozowski, M., Neuenswander, B., Lushington, G. H., & Hanson, P. R. (2010). SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides. Journal of Combinatorial Chemistry, 12(6), 850–854. http://doi.org/10.1021/cc1001023 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24260 | |
dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc1001023. | en_US |
dc.description.abstract | The construction of a library of benzothiaoxazepine-1,1’-dioxides utilizing a one-pot, SNAr diversification – ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation. | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | Copyright © American Chemical Society | en_US |
dc.subject | Sultams | en_US |
dc.subject | SNAr | en_US |
dc.subject | Microwave | en_US |
dc.subject | ODCT | en_US |
dc.subject | ROMP | en_US |
dc.subject | Scavenging | en_US |
dc.title | SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Rolfe, Alan | |
kusw.kuauthor | Samarakoon, Thiwanka B. | |
kusw.kuauthor | Klimberg, Sarra V. | |
kusw.kuauthor | Brzozowski, Marek | |
kusw.kuauthor | Neuenswander, Benjamin | |
kusw.kuauthor | Lushington, Gerald H. | |
kusw.kuauthor | Hanson, Paul R. | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.1021/cc1001023 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC3098767 | en_US |
dc.rights.accessrights | openAccess |