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dc.contributor.authorRolfe, Alan
dc.contributor.authorSamarakoon, Thiwanka Bandara
dc.contributor.authorKlimberg, Sarra V.
dc.contributor.authorBrzozowski, Marek
dc.contributor.authorNeuenswander, Benjamin
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorHanson, Paul R.
dc.date.accessioned2017-05-22T16:29:16Z
dc.date.available2017-05-22T16:29:16Z
dc.date.issued2010-11-08
dc.identifier.citationRolfe, A., Samarakoon, T. B., Klimberg, S. V., Brzozowski, M., Neuenswander, B., Lushington, G. H., & Hanson, P. R. (2010). SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides. Journal of Combinatorial Chemistry, 12(6), 850–854. http://doi.org/10.1021/cc1001023en_US
dc.identifier.urihttp://hdl.handle.net/1808/24260
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc1001023.en_US
dc.description.abstractThe construction of a library of benzothiaoxazepine-1,1’-dioxides utilizing a one-pot, SNAr diversification – ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsCopyright © American Chemical Societyen_US
dc.subjectSultamsen_US
dc.subjectSNAren_US
dc.subjectMicrowaveen_US
dc.subjectODCTen_US
dc.subjectROMPen_US
dc.subjectScavengingen_US
dc.titleSNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxidesen_US
dc.typeArticleen_US
kusw.kuauthorRolfe, Alan
kusw.kuauthorSamarakoon, Thiwanka B.
kusw.kuauthorKlimberg, Sarra V.
kusw.kuauthorBrzozowski, Marek
kusw.kuauthorNeuenswander, Benjamin
kusw.kuauthorLushington, Gerald H.
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1021/cc1001023en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3098767en_US
dc.rights.accessrightsopenAccess


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