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    SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides

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    Rolfe_2010.pdf (464.1Kb)
    Issue Date
    2010-11-08
    Author
    Rolfe, Alan
    Samarakoon, Thiwanka Bandara
    Klimberg, Sarra V.
    Brzozowski, Marek
    Neuenswander, Benjamin
    Lushington, Gerald H.
    Hanson, Paul R.
    Publisher
    American Chemical Society
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    Copyright © American Chemical Society
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    Abstract
    The construction of a library of benzothiaoxazepine-1,1’-dioxides utilizing a one-pot, SNAr diversification – ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.
    Description
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc1001023.
    URI
    http://hdl.handle.net/1808/24260
    DOI
    https://doi.org/10.1021/cc1001023
    Collections
    • Chemistry Scholarly Works [616]
    Citation
    Rolfe, A., Samarakoon, T. B., Klimberg, S. V., Brzozowski, M., Neuenswander, B., Lushington, G. H., & Hanson, P. R. (2010). SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides. Journal of Combinatorial Chemistry, 12(6), 850–854. http://doi.org/10.1021/cc1001023

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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