SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides

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Issue Date
2010-11-08Author
Rolfe, Alan
Samarakoon, Thiwanka Bandara
Klimberg, Sarra V.
Brzozowski, Marek
Neuenswander, Benjamin
Lushington, Gerald H.
Hanson, Paul R.
Publisher
American Chemical Society
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
Copyright © American Chemical Society
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Show full item recordAbstract
The construction of a library of benzothiaoxazepine-1,1’-dioxides utilizing a one-pot, SNAr diversification – ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.
Description
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc1001023.
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Citation
Rolfe, A., Samarakoon, T. B., Klimberg, S. V., Brzozowski, M., Neuenswander, B., Lushington, G. H., & Hanson, P. R. (2010). SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides. Journal of Combinatorial Chemistry, 12(6), 850–854. http://doi.org/10.1021/cc1001023
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