| dc.contributor.author | Dou, Dengfeng | |
| dc.contributor.author | Viwanathan, Prasanth | |
| dc.contributor.author | Li, Yi | |
| dc.contributor.author | He, Guijia | |
| dc.contributor.author | Alliston, Kevin R. | |
| dc.contributor.author | Lushington, Gerald H. | |
| dc.contributor.author | Brown-Clay, Joshua D. | |
| dc.contributor.author | Padmanabhan, Radhakrishnan | |
| dc.contributor.author | Groutas, William C. | |
| dc.date.accessioned | 2017-05-22T16:17:10Z | |
| dc.date.available | 2017-05-22T16:17:10Z | |
| dc.date.issued | 2010-11 | |
| dc.identifier.citation | Dou, D., Viwanathan, P., Li, Y., He, G., Alliston, K. R., Lushington, G. H., … Groutas, W. C. (2010). Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds. Journal of Combinatorial Chemistry, 12(6), 836–843. http://doi.org/10.1021/cc100091h | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/24258 | |
| dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc100091h. | en_US |
| dc.description.abstract | The 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have lead to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases. | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | Copyright © American Chemical Society | en_US |
| dc.title | Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4- tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Lushington, Gerald H. | |
| kusw.kudepartment | Chemistry | en_US |
| kusw.oanotes | Per SHERPA/RoMEO 5/22/2017: Author's Pre-print: grey tick subject to Restrictions below, author can archive pre-print (ie pre-refereeing)
Restrictions: Must obtain written permission from Editor
Must not violate ACS ethical GuidelinesAuthor's Post-print: grey tick subject to Restrictions below, author can archive post-print (ie final draft post-refereeing)
Restrictions: If mandated by funding agency or employer/ institution
If mandated to deposit before 12 months, must obtain waiver from Institution/Funding agency or use AuthorChoice
12 months embargoPublisher's Version/PDF: cross author cannot archive publisher's version/PDF
General Conditions: On author's personal website, pre-print servers, institutional website, institutional repositories or subject repositories
Non-Commercial
Must be accompanied by set statement (see policy)
Must link to publisher version
Publisher's version/PDF cannot be used | en_US |
| dc.identifier.doi | 10.1021/cc100091h | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC2975906 | en_US |
| dc.rights.accessrights | openAccess | |
