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    Quantitative analysis of aqueous phase composition of model dentin adhesives experiencing phase separation

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    Ye_2012.pdf (992.4Kb)
    Issue Date
    2012-05
    Author
    Ye, Qiang
    Park, Jonggu
    Parthasarathy, Ranganathan
    Pamatmat, Francis
    Misra, Anil
    Laurence, Jennifer S.
    Marangos, Orestes
    Spencer, Paulette
    Publisher
    Wiley
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    This is the peer reviewed version of the following article:Ye, Q., Park, J., Parthasarathy, R., Pamatmat, F., Misra, A., Laurence, J. S., Marangos, O. and Spencer, P. (2012), Quantitative analysis of aqueous phase composition of model dentin adhesives experiencing phase separation. J. Biomed. Mater. Res., 100B: 1086–1092. doi:10.1002/jbm.b.32675. Which has been published in final form at http://doi.org/10.1002/jbm.b.32675. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
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    Abstract
    There have been reports of the sensitivity of our current dentin adhesives to excess moisture, for example, water-blisters in adhesives placed on over-wet surfaces, and phase separation with concomitant limited infiltration of the critical dimethacrylate component into the demineralized dentin matrix. To determine quantitatively the hydrophobic/hydrophilic components in the aqueous phase when exposed to over-wet environments, model adhesives were mixed with 16, 33, and 50 wt % water to yield well-separated phases. Based upon high-performance liquid chromatography coupled with photodiode array detection, it was found that the amounts of hydrophobic BisGMA and hydrophobic initiators are less than 0.1 wt % in the aqueous phase. The amount of these compounds decreased with an increase in the initial water content. The major components of the aqueous phase were hydroxyethyl methacrylate (HEMA) and water, and the HEMA content ranged from 18.3 to 14.7 wt %. Different BisGMA homologues and the relative content of these homologues in the aqueous phase have been identified; however, the amount of crosslinkable BisGMA was minimal and, thus, could not help in the formation of a crosslinked polymer network in the aqueous phase. Without the protection afforded by a strong crosslinked network, the poorly photoreactive compounds of this aqueous phase could be leached easily. These results suggest that adhesive formulations should be designed to include hydrophilic multimethacrylate monomers and water compatible initiators.
    URI
    http://hdl.handle.net/1808/24247
    DOI
    https://doi.org/10.1002/jbm.b.32675
    Collections
    • Bioengineering Program Scholarly Works [144]
    Citation
    Ye, Q., Park, J., Parthasarathy, R., Pamatmat, F., Misra, A., Laurence, J. S., Marangos, O. and Spencer, P. (2012), Quantitative analysis of aqueous phase composition of model dentin adhesives experiencing phase separation. J. Biomed. Mater. Res., 100B: 1086–1092. doi:10.1002/jbm.b.32675

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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