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Three-dimensional Macroscopic Scaffolds With a Gradient in Stiffness for Functional Regeneration of Interfacial Tissues
dc.contributor.author | Singh, Milind | |
dc.contributor.author | Dormer, Nathan Henry | |
dc.contributor.author | Salash, Jean Remy | |
dc.contributor.author | Christian, Jordan M. | |
dc.contributor.author | Moore, David S. | |
dc.contributor.author | Berkland, Cory J. | |
dc.contributor.author | Detamore, Michael S. | |
dc.date.accessioned | 2017-05-19T15:32:42Z | |
dc.date.available | 2017-05-19T15:32:42Z | |
dc.date.issued | 2010-09-01 | |
dc.identifier.citation | Singh, M., Dormer, N., Salash, J. R., Christian, J. M., Moore, D. S., Berkland, C. and Detamore, M. S. (2010), Three-dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues. J. Biomed. Mater. Res., 94A: 870–876. doi:10.1002/jbm.a.32765 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24244 | |
dc.description.abstract | A novel approach has been demonstrated to construct biocompatible, macroporous 3-D tissue engineering scaffolds containing a continuous macroscopic gradient in composition that yields a stiffness gradient along the axis of the scaffold. Polymeric microspheres, made of poly(d,l-lactic-co-glycolic acid) (PLGA), and composite microspheres encapsulating a higher stiffness nano-phase material (PLGA encapsulating CaCO3 or TiO2 nanoparticles) were used for the construction of microsphere-based scaffolds. Using controlled infusion of polymeric and composite microspheres, gradient scaffolds displaying an anisotropic macroscopic distribution of CaCO3/TiO2 were fabricated via an ethanol sintering technique. The controllable mechanical characteristics and biocompatible nature of these scaffolds warrants further investigation for interfacial tissue engineering applications. | en_US |
dc.publisher | Wiley | en_US |
dc.rights | This is the peer reviewed version of the following article: Singh, M., Dormer, N., Salash, J. R., Christian, J. M., Moore, D. S., Berkland, C. and Detamore, M. S. (2010), Three-dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues. J. Biomed. Mater. Res., 94A: 870–876. doi:10.1002/jbm.a.32765. Which has been published in final form at http://10.1002/jbm.a.32765. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving | en_US |
dc.subject | Gradient | en_US |
dc.subject | Interfacial tissue | en_US |
dc.subject | Tissue engineering | en_US |
dc.subject | Composite materials | en_US |
dc.subject | Stiffness | en_US |
dc.title | Three-dimensional Macroscopic Scaffolds With a Gradient in Stiffness for Functional Regeneration of Interfacial Tissues | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Dormer, Nathan | |
kusw.kuauthor | Salash, Jean R. | |
kusw.kuauthor | Christian, Jordan M. | |
kusw.kuauthor | Moore, David S. | |
kusw.kuauthor | Berkland, Cory J. | |
kusw.kuauthor | Detamore, Michael S. | |
kusw.kudepartment | Chemical and Petroleum Engineering | en_US |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1002/jbm.a.32765 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2926291 | en_US |
dc.rights.accessrights | openAccess |