Three-dimensional Macroscopic Scaffolds With a Gradient in Stiffness for Functional Regeneration of Interfacial Tissues
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Issue Date
2010-09-01Author
Singh, Milind
Dormer, Nathan Henry
Salash, Jean Remy
Christian, Jordan M.
Moore, David S.
Berkland, Cory J.
Detamore, Michael S.
Publisher
Wiley
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
This is the peer reviewed version of the following article: Singh, M., Dormer, N., Salash, J. R., Christian, J. M., Moore, D. S., Berkland, C. and Detamore, M. S. (2010), Three-dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues. J. Biomed. Mater. Res., 94A: 870–876. doi:10.1002/jbm.a.32765. Which has been published in final form at http://10.1002/jbm.a.32765. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
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Show full item recordAbstract
A novel approach has been demonstrated to construct biocompatible, macroporous 3-D tissue engineering scaffolds containing a continuous macroscopic gradient in composition that yields a stiffness gradient along the axis of the scaffold. Polymeric microspheres, made of poly(d,l-lactic-co-glycolic acid) (PLGA), and composite microspheres encapsulating a higher stiffness nano-phase material (PLGA encapsulating CaCO3 or TiO2 nanoparticles) were used for the construction of microsphere-based scaffolds. Using controlled infusion of polymeric and composite microspheres, gradient scaffolds displaying an anisotropic macroscopic distribution of CaCO3/TiO2 were fabricated via an ethanol sintering technique. The controllable mechanical characteristics and biocompatible nature of these scaffolds warrants further investigation for interfacial tissue engineering applications.
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Citation
Singh, M., Dormer, N., Salash, J. R., Christian, J. M., Moore, D. S., Berkland, C. and Detamore, M. S. (2010), Three-dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues. J. Biomed. Mater. Res., 94A: 870–876. doi:10.1002/jbm.a.32765
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