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dc.contributor.authorEl-Gendy, Nashwa
dc.contributor.authorBerkland, Cory J.
dc.identifier.citationEl-Gendy, Nashwa, and Cory Berkland. “Combination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomeration.” Pharmaceutical research 26.7 (2009): 1752–1763.en_US
dc.descriptionThe original publication is available at www.springerlink.comen_US

To develop an aerosol system for efficient local lung delivery of chemotherapeutics where nanotechnology holds tremendous potential for developing more valuable cancer therapies. Concurrently, aerosolized chemotherapy is generating interest as a means to treat certain types of lung cancer more effectively with less systemic exposure to the compound.


Nanoparticles of the potent anticancer drug, paclitaxel, were controllably assembled to form low density microparticles directly after preparation of the nanoparticle suspension. The amino acid, L-leucine, was used as a colloid destabilizer to drive the assembly of paclitaxel nanoparticles. A combination chemotherapy aerosol was formed by assembling the paclitaxel nanoparticles in the presence of cisplatin in solution.


Freeze-dried powders of the combination chemotherapy possessed desirable aerodynamic properties for inhalation. In addition, the dissolution rates of dried nanoparticle agglomerate formulations (~60% to 66% after 8 h) were significantly faster than that of micronized paclitaxel powder as received (~18% after 8 h). Interestingly, the presence of the water soluble cisplatin accelerated the dissolution of paclitaxel.


Nanoparticle agglomerates of paclitaxel alone or in combination with cisplatin may serve as effective chemotherapeutic dry powder aerosols to enable regional treatment of certain lung cancers.
dc.publisherAmerican Association of Pharmaceutical Scientistsen_US
dc.subjectCombination chemotherapyen_US
dc.subjectDry powderen_US
dc.subjectNanoparticle agglomeratesen_US
dc.titleCombination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomerationen_US
kusw.kuauthorBerkland, Cory
kusw.kudepartmentPharmaceutical Chemistryen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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