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    Combination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomeration

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    Issue Date
    2009-05-05
    Author
    El-Gendy, Nashwa
    Berkland, Cory J.
    Publisher
    American Association of Pharmaceutical Scientists
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Purpose

    To develop an aerosol system for efficient local lung delivery of chemotherapeutics where nanotechnology holds tremendous potential for developing more valuable cancer therapies. Concurrently, aerosolized chemotherapy is generating interest as a means to treat certain types of lung cancer more effectively with less systemic exposure to the compound.

    Methods

    Nanoparticles of the potent anticancer drug, paclitaxel, were controllably assembled to form low density microparticles directly after preparation of the nanoparticle suspension. The amino acid, L-leucine, was used as a colloid destabilizer to drive the assembly of paclitaxel nanoparticles. A combination chemotherapy aerosol was formed by assembling the paclitaxel nanoparticles in the presence of cisplatin in solution.

    Results

    Freeze-dried powders of the combination chemotherapy possessed desirable aerodynamic properties for inhalation. In addition, the dissolution rates of dried nanoparticle agglomerate formulations (~60% to 66% after 8 h) were significantly faster than that of micronized paclitaxel powder as received (~18% after 8 h). Interestingly, the presence of the water soluble cisplatin accelerated the dissolution of paclitaxel.

    Conclusions

    Nanoparticle agglomerates of paclitaxel alone or in combination with cisplatin may serve as effective chemotherapeutic dry powder aerosols to enable regional treatment of certain lung cancers.
    Description
    The original publication is available at www.springerlink.com
    URI
    http://hdl.handle.net/1808/24088
    DOI
    https://doi.org/10.1007/s11095-009-9886-2
    Collections
    • Pharmaceutical Chemistry Scholarly Works [353]
    Citation
    El-Gendy, Nashwa, and Cory Berkland. “Combination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomeration.” Pharmaceutical research 26.7 (2009): 1752–1763.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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