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    Understanding phenotypic variation in rodent models with germline Apc mutations

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    Zeineldin_AACR_2013.pdf (433.5Kb)
    Issue Date
    2013-04-15
    Author
    Zeineldin, Maged
    Neufeld, Kristi L.
    Publisher
    AACR
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    ©2013 American Association for Cancer Research.
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    Abstract
    Adenomatous Polyposis Coli (APC) is best known for its crucial role in colorectal cancer suppression. Rodent models with various Apc mutations have enabled experimental validation of different Apc functions in tumors and normal tissues. Since the development of the first mouse model with a germline Apc mutation in the early 1990s, twenty other Apc mouse and rat models have been generated. This article compares and contrasts currently available Apc rodent models with particular emphasis on providing potential explanations for their reported variation in three areas: 1) intestinal polyp multiplicity, 2) intestinal polyp distribution, and 3) extra intestinal phenotypes.
    URI
    http://hdl.handle.net/1808/24083
    DOI
    https://doi.org/10.1158/0008-5472.CAN-12-4607
    Collections
    • Molecular Biosciences Scholarly Works [531]
    Citation
    Zeineldin, M., & Neufeld, K. L. (2013). Understanding phenotypic variation in rodent models with germline Apc mutations. Cancer Research, 73(8), 2389–2399. http://doi.org/10.1158/0008-5472.CAN-12-4607

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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