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dc.contributor.authorHasan, Anwarul
dc.contributor.authorPaul, Arghya
dc.contributor.authorMemic, Adnan
dc.contributor.authorKhademhosseini, Ali
dc.date.accessioned2017-05-10T17:19:36Z
dc.date.available2017-05-10T17:19:36Z
dc.date.issued2015-10
dc.identifier.citationHasan, A., Paul, A., Memic, A., & Khademhosseini, A. (2015). A multilayered microfluidic blood vessel-like structure. Biomedical Microdevices, 17(5), 88. http://doi.org/10.1007/s10544-015-9993-2en_US
dc.identifier.urihttp://hdl.handle.net/1808/24070
dc.descriptionThe final publication is available at Springer via http://dx.doi.org/10.1007/s10544-015-9993-2en_US
dc.description.abstractThere is an immense need for tissue engineered blood vessels. However, current tissue engineering approaches still lack the ability to build native blood vessel-like perfusable structures with multi-layered vascular walls. This paper demonstrated a new method to fabricate tri-layer biomimetic blood vessel-like structures on a microfluidic platform using photocrosslinkable gelatin hydrogel. The presented method enables fabrication of physiological blood vessel-like structures with mono-, bi- or tri-layer vascular walls. The diameter of the vessels, the total thickness of the vessel wall and the thickness of each individual layer of the wall were independently controlled. The developed fabrication process is a simple and rapid method, allowing the physical fabrication of the vascular structure in minutes, and the formation of a vascular endothelial cell layer inside the vessels in 3–5 days. The fabricated vascular constructs can potentially be used in numerous applications including drug screening, development of in vitro models for cardiovascular diseases and/or cancer metastasis, and study of vascular biology and mechanobiology.en_US
dc.publisherSpringer Verlagen_US
dc.rights© Springer Science+Business Media New York 2015en_US
dc.subjectTissue engineeringen_US
dc.subjectMicrofluidicsen_US
dc.subjectBlood vesselen_US
dc.subjectHydrogelen_US
dc.subjectPDMSen_US
dc.subjectMicrofabricationen_US
dc.titleA multilayered microfluidic blood vessel-like structureen_US
dc.typeArticleen_US
kusw.kuauthorPaul, Arghya
kusw.kudepartmentChemical and Petroleum Engineeringen_US
dc.identifier.doi10.1007/s10544-015-9993-2en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4890640en_US
dc.rights.accessrightsopenAccess


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