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    A multilayered microfluidic blood vessel-like structure

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    Hasan_Springer_2015.pdf (2.052Mb)
    Issue Date
    2015-10
    Author
    Hasan, Anwarul
    Paul, Arghya
    Memic, Adnan
    Khademhosseini, Ali
    Publisher
    Springer Verlag
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    © Springer Science+Business Media New York 2015
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    Abstract
    There is an immense need for tissue engineered blood vessels. However, current tissue engineering approaches still lack the ability to build native blood vessel-like perfusable structures with multi-layered vascular walls. This paper demonstrated a new method to fabricate tri-layer biomimetic blood vessel-like structures on a microfluidic platform using photocrosslinkable gelatin hydrogel. The presented method enables fabrication of physiological blood vessel-like structures with mono-, bi- or tri-layer vascular walls. The diameter of the vessels, the total thickness of the vessel wall and the thickness of each individual layer of the wall were independently controlled. The developed fabrication process is a simple and rapid method, allowing the physical fabrication of the vascular structure in minutes, and the formation of a vascular endothelial cell layer inside the vessels in 3–5 days. The fabricated vascular constructs can potentially be used in numerous applications including drug screening, development of in vitro models for cardiovascular diseases and/or cancer metastasis, and study of vascular biology and mechanobiology.
    Description
    The final publication is available at Springer via http://dx.doi.org/10.1007/s10544-015-9993-2
    URI
    http://hdl.handle.net/1808/24070
    DOI
    https://doi.org/10.1007/s10544-015-9993-2
    Collections
    • Chemical & Petroleum Engineering Scholarly Works [177]
    Citation
    Hasan, A., Paul, A., Memic, A., & Khademhosseini, A. (2015). A multilayered microfluidic blood vessel-like structure. Biomedical Microdevices, 17(5), 88. http://doi.org/10.1007/s10544-015-9993-2

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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